Chiral dihydroxytetraphenylene-catalyzed enantioselective conjugate addition of boronic acids to β-enaminones

We report the (S)-2,15-Cl-2-DHTP-catalyzed enantioselective conjugate addition of organic boronic acids to beta-enaminones, providing the corresponding addition products in high yields and moderate to excellent enantioselectivities (up to 98% ee). This catalytic system exhibits unique features in terms of mild reaction conditions, high efficiency, broad substrate scope, and the applicability of alkenylboronic acids and heteroarylboronic acids.

Automated summary

We report the enantioselective conjugate addition of organic boronic acids to beta-enaminones catalyzed by (S)-2,15-Cl-2-DHTP, providing high yields and moderate to excellent enantioselectivities (up to 98% ee). This catalytic system exhibits unique features including mild reaction conditions, high efficiency, broad substrate scope, and applicability to alkenylboronic acids and heteroarylboronic acids.