4.3 Review

Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma: a review of clinical data

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Autologous transplant vs chimeric antigen receptor T-cell therapy for relapsed DLBCL in partial remission

Mazyar Shadman et al.

Summary: The relative efficacy of autologous hematopoietic cell transplant (auto-HCT) vs chimeric antigen receptor T-cell (CAR-T) therapy in patients with diffuse large B-cell lymphoma (DLBCL) who achieve a partial remission (PR) after salvage chemotherapy is not known. A study found that auto-HCT treatment was associated with a lower rate of relapse and superior overall survival compared to CAR-T treatment in DLBCL patients in PR after salvage therapy. These findings support auto-HCT as the standard of care for transplant-eligible patients with relapsed DLBCL in PR after salvage therapy.
Article Medicine, General & Internal

Second-Line Tisagenlecleucel or Standard Care in Aggressive B-Cell Lymphoma

M. R. Bishop et al.

Summary: Tisagenlecleucel did not demonstrate superiority over standard salvage therapy in this trial. Further studies are needed to evaluate which patients may benefit the most from each approach.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Medicine, General & Internal

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma

F. L. Locke et al.

Summary: This international phase 3 trial showed that axicabtagene ciloleucel therapy significantly improved event-free survival and response in patients with early relapsed or refractory large B-cell lymphoma compared to standard care, despite the expected high-grade toxic effects.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Oncology

Health-Related Quality of Life, Symptoms, and Tolerability of Loncastuximab Tesirine in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Alexander Spira et al.

Summary: This study evaluated the effects of loncastuximab tesirine on HRQoL, symptoms, and tolerability in patients with relapsed or refractory DLBCL. During treatment, patients showed improvement in overall health scores and reported improvement in symptoms such as pain, lumps/swelling, and weight loss.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2022)

Article Hematology

Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma

Mehdi Hamadani et al.

Summary: Loncastuximab tesirine, an antibody-drug conjugate, shows promising efficacy and safety in patients with relapsed or refractory B-cell non-Hodgkin lymphoma, especially for certain specific lymphoma subtypes. This study suggests that loncastuximab tesirine could be a valuable treatment option for these patients and warrants further investigation in phase 2 trials.
Article Hematology

Is autologous transplant in relapsed DLBCL patients achieving only a PET+ PR appropriate in the CAR T-cell era?

Nirav N. Shah et al.

Summary: For relapsed chemosensitive DLBCL patients with residual PET/CT+ disease prior to auto-HCT, the adjusted 5-year PFS was comparable, irrespective of time to relapse. These data support ongoing application of auto-HCT in chemosensitive DLBCL.
Article Oncology

Loncastuximab tesirine in relapsed or refractory diffuse large B-cell lymphoma (LOTIS-2): a multicentre, open-label, single-arm, phase 2 trial

Paolo F. Caimi et al.

Summary: Loncastuximab tesirine shows substantial antitumor activity and acceptable safety profile in patients with relapsed or refractory DLBCL, potentially offering a new therapeutic option for heavily pretreated individuals.

LANCET ONCOLOGY (2021)

Article Oncology

Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Laurie H. Sehn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Article Oncology

Point mutation inCD19facilitates immune escape of B cell lymphoma from CAR-T cell therapy

Zhen Zhang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Chemistry, Medicinal

Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Arnaud C. Tiberghien et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Article Biochemistry & Molecular Biology

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

Wyndham H. Wilson et al.

NATURE MEDICINE (2015)

Review Pharmacology & Pharmacy

The development of pyrrolobenzodiazepines as antitumour agents

John A. Hartley

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2011)

Article Oncology

Salvage Regimens With Autologous Transplantation for Relapsed Large B-Cell Lymphoma in the Rituximab Era

Christian Gisselbrecht et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Medicine, General & Internal

CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.

B Coiffier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)