Base-controlled dearomative [3+2] cycloadditions between 3-nitro-indoles and fumaric acid amide esters

The base-controlled dearomative [3 + 2] cycloaddition reaction between 3-nitroindoles and fumaric acid amide esters has been disclosed by using the dearomatization and aromatization strategy. Three kinds of diverse functionalized pyrrolo[2,3-b]indole derivatives were obtained respectively with excellent chemoselectivities and good diastereoselectivities using different bases.

Automated summary

The base-controlled dearomative [3 + 2] cycloaddition reaction between 3-nitroindoles and fumaric acid amide esters was investigated using the dearomatization and aromatization strategy. Three different functionalized pyrrolo[2,3-b]indole derivatives were obtained with excellent chemoselectivities and good diastereoselectivities using various bases.