期刊
CLOCKS & SLEEP
卷 4, 期 1, 页码 66-79出版社
MDPI
DOI: 10.3390/clockssleep4010008
关键词
sleep; circadian rhythms; COVID-19; coronavirus; SARS-CoV-2; cold; immune function; vaccination
Sleep and circadian rhythms are closely linked to the immune system and vaccination success. Lack of sleep and poor sleep quality can increase vulnerability, while sleep duration and timing may affect antibody response after vaccination. It is recommended to have at least 7 hours of sleep every night to reduce infection risk and optimize vaccine efficacy.
Sleep and circadian rhythms are closely involved in the immune system and its regulation. Here, we describe this relationship and provide recommendations regarding the influence of sleep and circadian rhythms on vaccination success. We review studies investigating how viral susceptibility is influenced by changes in immunological parameters as a consequence of sleep deprivation. Short sleep duration and poor sleep efficiency both appear to be strong factors leading to greater vulnerability. In addition, both sleep duration and the time of day of the vaccination seem to be associated with the magnitude of the antibody response after vaccination. Based on these findings, a recommendation would consist of a sleep duration of 7 h or more every night to both reduce the risk of infection and to optimize the efficacy of vaccination with respect to circadian timing. Improving sleep quality and its circadian timing can potentially play a role in preventing infection and in vaccination benefits. In conclusion, sufficient (or longer) sleep duration is important in both reducing susceptibility to infection and increasing antibody response after vaccination.
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