期刊
SIGNAL TRANSDUCTION AND TARGETED THERAPY
卷 7, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41392-022-00900-8
关键词
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资金
- NNSF of China [62120106002, 52103166]
- Jiangsu Province Policy Guidance Plan [BZ2019014]
- Natural Science Foundation of Jiangsu Province [BK20200710]
- 'Taishan scholars' construction special fund of Shandong Province
This article introduces a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance, which exhibits satisfactory bactericidal performance against MRSA.
The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (similar to 99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag+. As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electronhole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O-2 to center dot O-2 Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo5+/Mo6+, further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.
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