期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 17, 页码 3303-3310出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb00141a
关键词
-
资金
- Czech Science Foundation [21-11688S]
X-ray-induced photodynamic therapy, utilizing radiosensitizing nanoparticles to produce reactive oxygen species, offers a promising modality for the treatment of various malignancies. It overcomes the limitations of conventional photodynamic therapy and reduces the required dose for cancer eradication within radiotherapy treatment.
X-Ray-induced photodynamic therapy represents a suitable modality for the treatment of various malignancies. It is based on the production of reactive oxygen species by radiosensitizing nanoparticles activated by X-rays. Hence, it allows overcoming the depth-penetration limitations of conventional photodynamic therapy and, at the same time, reducing the dose needed to eradicate cancer in the frame of radiotherapy treatment. The direct production of singlet oxygen by octahedral molybdenum cluster complexes upon X-ray irradiation is a promising avenue in order to simplify the architecture of radiosensitizing systems. One such complex was utilized to prepare water-stable nanoparticles using the solvent displacement method. The nanoparticles displayed intense red luminescence in aqueous media, efficiently quenched by oxygen to produce singlet oxygen, resulting in a substantial photodynamic effect under blue light irradiation. A robust radiosensitizing effect of the nanoparticles was demonstrated in vitro against TRAMP-C2 murine prostatic carcinoma cells at typical therapeutic X-ray doses. Injection of a suspension of the nanoparticles to a mouse model revealed the absence of acute toxicity as evidenced by the invariance of key physiological parameters. This study paves the way for the application of octahedral molybdenum cluster-based radiosensitizers in X-ray-induced photodynamic therapy and its translation to in vivo experiments.
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