Organophotoredox catalytic four-component radical-polar crossover cascade reactions for the stereoselective synthesis of β-amido sulfones

Multicomponent diastereoselective synthesis is still very difficult to achieve in photoredox catalysis. Here, we report a green and reliable strategy for the diastereoselective synthesis of beta-amido sulfones through organophotoredox catalytic four-component radical-polar crossover cascade reactions. This transformation features excellent atom-, step-, and redox economy and diastereoselectivity. Moreover, DFT calculation studies were performed to provide some insights into the origin of diastereoselectivity.

Automated summary

In this study, a green and reliable strategy for the diastereoselective synthesis of beta-amido sulfones through organophotoredox catalytic four-component radical-polar crossover cascade reactions was reported. The transformation exhibited excellent atom-, step-, and redox economy as well as diastereoselectivity.