期刊
ENDOCRINOLOGIA Y NUTRICION
卷 63, 期 4, 页码 171-180出版社
ELSEVIER DOYMA SL
DOI: 10.1016/j.endonu.2015.11.004
关键词
GH; E2; Testosterone; Liver; Metabolism; Sexual dimorphism
资金
- Spanish Ministry of Economy and Competitivity (MINECO)
- European Regional Development Fund-European Social Fund [SAF2012-37344]
- Canary Islands Government [ACIISI PI2010]
- Alfredo Martin-Reyes Foundation (Arehucas)-FICIC
GH and sex hormones are critical regulators of body growth and composition, somatic development, intermediate metabolism, and sexual dimorphism. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Effects of sex hormones on the liver may be direct, through hepatic receptors, or indirect by mod ulating endocrine, metabolic, and gender -differentiated functions of GH. Sex hormones can modulate GH actions by acting centrally, regulating pituitary GH secretion, and peripherally, by modulating GH signaling pathways. The endocrine and/or metabolic consequences of long-term exposure to sex hormone -related compounds and their influence on the GH-liver axis are largely unknown. A better understanding of these interactions in physiological and pathological states will contribute to preserve health and to improve clinical management of patients with growth, developmental, and metabolic disorders. (C) 2015 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
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