☆ 4.7 Letter

Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Zhenfeng Wang et al.

Summary: The study demonstrates the potential therapeutic effect of ACE2-overexpressing A549 cell-derived microparticles (AO-MPs) against SARS-CoV-2 infection by changing endosomal pH and promoting viral degradation. In addition to inhibiting the inflammatory response of alveolar macrophages, AO-MPs increase treatment efficacy in a SARS-CoV-2-infected mouse model without side effects, highlighting the potential use of AO-MPs in treating SARS-CoV-2-infected patients and the feasibility of microparticle therapies for combating emerging respiratory viruses in the future.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Timothy N. Hoang et al.

Summary: The study found that in a rhesus macaque model of SARS-CoV-2 infection, baricitinib did not reduce viral shedding, but did decrease inflammation and suppress the production of cytokines and chemokines, suggesting its potential as an effective treatment for COVID-19 inflammation.

CELL (2021)

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Article Multidisciplinary Sciences

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Rogan A. Grant et al.

Summary: The study found that patients infected with SARS-CoV-2 have enriched T cells and monocytes in the alveolar space, suggesting that the virus infects alveolar macrophages and induces T cell production of interferon-, leading to inflammation and persistent alveolitis.

NATURE (2021)

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Article Cell Biology

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

Jiadi Lv et al.

Summary: M1 alveolar macrophages facilitate the spread and replication of SARS-CoV-2, while M2 alveolar macrophages help degrade the virus to combat infection.

CELL DISCOVERY (2021)

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Letter Biochemistry & Molecular Biology

Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant

Zhenfeng Wang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

SPION primes THP1 derived M2 macrophages towards M1-like macrophages

Amit Laskar et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages

相关参考文献

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant

SPION primes THP1 derived M2 macrophages towards M1-like macrophages

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