4.6 Article

Real-time drug release monitoring from pH-responsive CuS-encapsulated metal-organic frameworks

期刊

RSC ADVANCES
卷 12, 期 18, 页码 11119-11127

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra09320g

关键词

-

资金

  1. Beijing Municipal Natural Science Foundation [7214300]
  2. Natural Science Foundation of China [82001946, 62175266]
  3. National Key R&D Program of China [2017YFB0405402]

向作者/读者索取更多资源

This study presents a metal-organic framework (MOF)-based nanotheranostic system that enables real-time drug release monitoring and combined chemo-photothermal therapy. By encapsulating photothermal agents (CuS) and therapeutic drug (DOX), the system achieves effective treatment while allowing drug release behaviors to be monitored in real-time. Moreover, the addition of folic acid-conjugated polyethylene glycol (FA-PEG) antennas enhances the active targeting effect of the system towards cancer cells.
Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal-organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据