期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 9, 页码 2557-2562出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00123c
关键词
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资金
- National Natural Science Foundation of China [22125108, 92056104, 21772161]
- Natural Science Foundation of Fujian Province of China [2019J02001]
- President Research Funds from Xiamen University [20720210002]
- NFFTBS [J1310024]
An efficient gold-catalyzed cascade cyclization has been developed for the synthesis of tetracyclic gamma-lactams bearing one quaternary carbon center and one tertiary carbon center. The reaction involves alkyne oxidation, carbene-alkyne metathesis, and cyclopropanation, and exhibits moderate to good yields with excellent diastereoselectivities. The proposed mechanistic rationale is well supported by theoretical calculations.
An efficient gold-catalyzed cascade cyclization of alkenyl diynes involving alkyne oxidation, carbene-alkyne metathesis and cyclopropanation has been developed, furnishing a series of tetracyclic gamma-lactams bearing one quaternary carbon center and one tertiary carbon center in moderate to good yields with excellent diastereoselectivities. In addition, the proposed mechanistic rationale for this oxidative cyclization is well supported by theoretical calculations.
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