3.9 Article

Optimization and Antibacterial Response of N-Halamine Coatings Based on Polydopamine

期刊

COLLOIDS AND INTERFACES
卷 6, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/colloids6010009

关键词

polydopamine coating; N-halamine; antibacterial surfaces; XPS; PM-RAIRS; microbiological tests

资金

  1. IMPC (Institut des Materiaux de Paris Centre, FR2482)
  2. C'Nano project of Region Ile-de-France
  3. European cross-border cooperation program Interreg Franco-Suisse 2014-2020
  4. FEDER agency (Fonds Europeen de Developpement Regional)
  5. French state funds [ANR-11-IDEX-0004-02]
  6. French Renatech network
  7. FEMTO-ST technological facility (SEM-FEG Imaging)

向作者/读者索取更多资源

Developing surfaces with antimicrobial properties is essential, and this study investigates polydopamine coatings containing chloramine functions. Different coatings were formed through immersion and chlorination processes, and their bactericidal properties were evaluated.
Due to the ability of microorganisms to first adhere to a material surface and then to lead to the formation of a biofilm, it is essential to develop surfaces that have antimicrobial properties. It is well known that N-halamine coatings allow us to prevent or minimize such phenomena. In the present work, various polydopamine (PDA) coatings containing chloramine functions were studied. In fact, three PDA-based films were formed by the simple immersion of a gold substrate in a dopamine solution, either at pH 8 in the presence or not of polyethyleneimine (PEI), or at pH 5 in the presence of periodate as an oxidant. These films were characterized by polarization modulation reflection absorption infrared spectroscopy and X-ray photoelectron spectroscopy analyses, and by scanning electron microscopy observations. The chlorination of these PDA films was performed by their immersion in a sodium hypochlorite aqueous solution, in order to immobilize Cl(+I) into the (co)polymers (PDA or PDA-PEI). Finally, antibacterial assays towards the Gram-negative bacteria Escherichia coli (E. coli) and the Gram-positive bacteria Staphylococcus epidermidis (S. epidermidis) were conducted to compare the bactericidal properties of these three N-halamine coatings. Regardless of the bacteria tested, the PDA coating with the best antibacterial properties is the coating obtained using periodate.

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