4.8 Article

Application of nanomaterials in proteomics-driven precision medicine

期刊

THERANOSTICS
卷 12, 期 6, 页码 2674-2686

出版社

IVYSPRING INT PUBL
DOI: 10.7150/thno.64325

关键词

Nanoparticle; nanotechnology; mass spectrometry; biomarkers; proteomics; post-translational modifications

资金

  1. National Key Research and Development Program of China [2020YFE0202200]
  2. National Science Foundation of China [21974026, 22174021, 21775053]
  3. innovative research team of high-level local university in Shanghai

向作者/读者索取更多资源

Nanostructured devices and nanoparticles have greatly advanced precision healthcare, while mass spectrometry-based proteomics has become a powerful tool for disease identification and drug development. The combination of these two disciplines has expanded our knowledge about human health and disease, with the help of nanotechnology-assisted sample processing strategies and emerging nanotechnologies.
Nanostructured devices and nanoparticles have fundamentally reshaped the development of precision healthcare in recent decades. Meanwhile, mass spectrometry (MS)-based proteomics has evolved from simple protein sequencing to a powerful approach that identifies disease patterns and signatures, reveals molecular mechanisms of pathological processes, and develops therapeutic or preventive drugs. Significantly, the two distinct disciplines have synergized and expanded our knowledge about human health and disease, as evidenced by a variety of nanotechnology-assisted sample processing strategies, facilitating in-depth proteome profiling and post-translational modifications (PTMs) characterization. This review summarizes recent advances in nanoparticle design for better enrichment of marker proteins and their PTMs from various bio-specimens and emerging nanotechnologies that are applied to MS-based proteomics for precision medicine discovery.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据