期刊
THERANOSTICS
卷 12, 期 6, 页码 2722-2740出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.71360
关键词
Metformin; aging; aging-related diseases; clinical application; molecular mechanism
资金
- National Key Research and Development Program of China [2019YFA0906004]
- National Natural Science Foundation of China [81991513, 81870532]
- Guangdong Provincial Science and Technology Innovation Council [2017B030301018]
Aging is a natural process that plays a critical role in the development of various diseases. Metformin, an antidiabetic drug, has been reported to delay aging and provide protection against aging-related diseases by impacting key events in the aging process.
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of diseases, i.e., aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease, cardiovascular diseases, cancers, obesity and other metabolic abnormalities. Metformin, the most widely used antidiabetic drug, has been reported to delay aging and display protective effect on attenuating progression of various aging-related diseases by impacting key hallmark events of aging, including dysregulated nutrient sensing, loss of proteostasis, mitochondrial dysfunction, altered intercellular communication, telomere attrition, genomic instability, epigenetic alterations, stem cell exhaustion and cellular senescence. In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating aging-related diseases.
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