期刊
MILITARY MEDICAL RESEARCH
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40779-022-00376-1
关键词
Spinal cord injury; Injectable hydrogels; Hydrogel scaffolds; Multimodal therapy
Spinal cord injury is a serious traumatic disease with complex pathological mechanism, and the treatment is still a huge challenge. Hydrogels have been identified as promising materials for SCI repair and studies have shown their effectiveness in reducing inflammation and promoting spinal cord repair.
Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of this disease still faces a huge challenge. Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord. Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration to improve SCI. In this review, hydrogel-based multimodal therapeutic strategies to repair SCI are provided, and a combination of hydrogel scaffolds and other therapeutic modalities are discussed, with particular emphasis on the repair mechanism of SCI.
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