期刊
ANIMAL NUTRITION
卷 8, 期 -, 页码 144-152出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.aninu.2021.06.009
关键词
Ferulic acid; Vanillic acid; Inflammation; Gut barrier function; Growth performance; Piglet
资金
- National Natural Science Foundation of China [31741115, 32102578]
- Fellowship of China Postdoctoral Science Foundation [2021T140715]
- Hunan Provincial Natural Science Foundation for Distinguished Young Scholars [2019JJ30012]
- Scientific Research Fund of Hunan Provincial Education Department [18B098]
The study demonstrated that both vanillic acid (VA) and ferulic acid (FA) can alleviate inflammation and oxidative stress, with VA having a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.
Ferulic acid (FA) and vanillic acid (VA) are considered as major phenolic metabolites of cyanidin 3-glucoside, a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous study. This study aimed to investigate the effect of FA and VA on inflammation, gut barrier function, and growth performance in a weaned piglet model challenged with lipopolysaccharide (LPS). Thirty-six piglets (PIC 337 x C48, 28 d of age) were randomly allocated into 3 treatments with 6 replicate pens (2 piglets per pen). They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or VA. Dietary supplementation of VA significantly increased average daily gain (ADG) (P < 0.05). Both FA and VA decreased serum levels of thiobarbituric acid reactive substances (TBARS), interlukin (IL)-1 beta, IL-2, IL-6, and tumor necrosis factor (TNF)-alpha (P < 0.05), and enhanced the expression of tight junction protein oclaudin (P < 0.05). Analysis of gut microbiota indicated that both FA and VA increased the Firmicutes/Bacteroidetes ratio alongside reducing the relative abundance of the Prevotellaceae family including Prevotella 9 and Prevotella 2 genera, but enriched the Lachoiraceaea family including the Lachnospiraceae FCS020 group (P < 0.05). Moreover, VA reduced the relative abundance of Prevotella 7 and Prevotella 1 but enriched Lachnospira, Eubacterium eligens group, and Eubacterium xylanophilum group (P < 0.05), while FA showed a limited effect on these genera. The results demonstrated that both VA and FA could alleviate inflammation and oxidative stress, but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota. (C) 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
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