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Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

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Summary: The first reported cases suggest a correlation between SARS-CoV-2 infections and Parkinson's disease (PD), but the causal link remains unclear. Through test tube experiments, researchers found that the nucleocapsid protein (N-protein) of SARS-CoV-2 significantly accelerates the aggregation of alpha-synuclein protein, a characteristic feature of PD. These findings indicate a direct molecular interaction between SARS-CoV-2 and alpha-synuclein, providing insight into the observed correlation.

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Summary: Increasing evidence suggests that microglial activation plays a crucial role in the initiation and progression of Parkinson's disease, with cell-to-cell propagation of alpha-synuclein pathology being a highlighted feature. Recent studies indicate that plasma exosomes from Parkinson's disease patients carry pathological alpha-synuclein and target microglia preferentially, suggesting their key role in investigating the transmission of alpha-synuclein by microglia.

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Summary: Research on the connection between COVID-19 and Parkinson's disease is ongoing, with some evidence suggesting a potential increase in neurodegenerative diseases following the SARS-CoV-2 pandemic. However, current data are not sufficient to confirm whether COVID-19 can directly trigger or accelerate neurodegenerative diseases.

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