4.5 Review

Emerging treatment strategies for metastatic triple-negative breast cancer

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A Phase I Trial of Talimogene Laherparepvec in Combination with Neoadjuvant Chemotherapy for the Treatment of Nonmetastatic Triple-Negative Breast Cancer

Hatem Soliman et al.

Summary: The study combined TVEC and NAC for TNBC treatment, with postoperative evaluation using RCB. It found that adding TVEC at approved dose was feasible and resulted in a complete response rate of 55%. Most patients tolerated the treatment well with manageable toxicities.

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Summary: Novel antibody-drug conjugates targeting HER2 have shown high activity in HER2-negative breast cancer with low HER2 expression, but the clinical and molecular characteristics of HER2-low breast cancer remain unclear. This study reveals that HER2-low is more common in HR-positive disease than in TNBC, and emphasizes the significant biological heterogeneity of HER2-low BC, highlighting the importance of reproducible and sensitive assays for measuring low HER2 expression.

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Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

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HER2-Low Breast Cancer: Molecular Characteristics and Prognosis

Elisa Agostinetto et al.

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Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer

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NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Resistance to Antibody-Drug Conjugates

Sara Garcia-Alonso et al.

CANCER RESEARCH (2018)

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Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

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NATURE MEDICINE (2018)

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Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

Jennifer K. Litton et al.

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Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

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Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

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OX40 agonists anc combination immunotherapy: putting the pedal to the metal

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PD-L1 Expression in Triple-Negative Breast Cancer

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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

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