☆ 4.7 Review

Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities

NATURE REVIEWS CANCER (2022)

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Article Biochemistry & Molecular Biology

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Roei D. Mazor et al.

Summary: This study found that somatic hypermutations (SHMs) promote antibody antitumor reactivity against surface autoantigens in high-grade serous ovarian carcinoma (HGSOC). The tumor-reactive antibodies target MMP14, which is abundantly expressed on the tumor cell surface. These findings highlight the origin and potential applicability of autoantibodies directed at surface antigens for tumor targeting in cancer patients.

CELL (2022)

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Article Immunology

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer

Maxime Meylan et al.

Summary: The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in renal cell carcinoma (RCC). B cells are enriched in TLS and demonstrate diverse maturation stages, with the presence of fully mature clonotypes. Additionally, IgG-and IgA-producing plasma cells (PCs) disseminate into the tumor beds along fibroblastic tracks in TLS+ tumors, indicating potential anti-tumor effector activity. Furthermore, the presence of IgG-stained tumor cells correlates with therapeutic responses and progression-free survival in RCC patients treated with immune checkpoint inhibitors.

IMMUNITY (2022)

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Review Immunology

Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases

Hiroyuki Yoshitomi et al.

Summary: The interactions between CD4(+)T cells and B cells are crucial for antibody responses and autoimmune diseases. Recent studies identified a new subset of CD4(+)B helper T cells called peripheral helper T (Tph) cells, which provide help to B cells in inflamed tissues and share some functions with Tfh cells.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Biology

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Alyssa Vito et al.

Summary: The combination immunotherapy platform in triple negative breast cancer increases tumor-infiltrating lymphocytes and improves response to immune checkpoint blockade. B cells play a crucial role in antitumor immunity and modulate myeloid-derived suppressor cells.

COMMUNICATIONS BIOLOGY (2021)

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Article Immunology

Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma

Catalina Lee-Chang et al.

Summary: The B-Vax vaccine developed in this study showed significant effects in activating autologous CD8(+) T cells and killing GBM cells, achieving an 80% tumor eradication rate in experimental animals.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Editorial Material Biochemistry & Molecular Biology

New at Cell Press: The Inclusion and Diversity Statement

Deborah J. Sweet

CELL (2021)

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Review Immunology

Regulatory B cells in cancer

Daniel Michaud et al.

Summary: Tumorigenesis involves genetic mutations and changes in the microenvironment, with immune cells in tumors playing a role in promoting tumor growth. Recent studies have shed light on the mechanisms of how B cells regulate immune responses, with negative regulation potentially impacting anti-tumor immune function through cytokine production.

IMMUNOLOGICAL REVIEWS (2021)

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Article Immunology

B cells and cancer: To B or not to B?

Wolf Herman Fridman et al.

Summary: Recent studies have suggested that B cells in the tumor microenvironment may play a significant role in presenting tumor-associated antigens to T cells and producing antibodies that enhance antigen presentation, ultimately impacting cancer clinical outcomes. Immune complexes formed by B cells can also have deleterious effects through inflammation, angiogenesis, and immunosuppression via macrophage and complement activation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Review Immunology

Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

Catarina Gago da Graca et al.

Summary: This review focuses on the role of lymph node stromal cells and TLSs in coordinating adaptive immune responses and their potential impact on diseases, particularly autoimmunity and cancer. The discussion includes recent findings on the function and formation of these structures and their possible role in promoting tolerance.

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Article Multidisciplinary Sciences

Defining HPV-specific B cell responses in patients with head and neck cancer

Andreas Wieland et al.

Summary: Detailed analyses of B cells in the tumor microenvironment of HPV-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ. The findings suggest that tumor-infiltrating B cells could potentially be utilized for the development of therapeutic agents in human cancer.

NATURE (2021)

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Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Oncology

A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinoma

Jan Budczies et al.

Summary: This study identified B cells and total TILs as complementary predictors of benefit from immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) through targeted gene expression profiling, which could potentially be integrated into routine diagnostic work-up alongside existing NGS protocols.

ONCOIMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

Baihao Zhang et al.

Summary: This study reveals that small metabolites like GABA derived from B-lineage cells can influence immune responses by promoting anti-inflammatory macrophages and enhancing anti-tumour responses. The findings suggest that targeting these metabolites may offer a new approach to immunoregulation.

NATURE (2021)

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Article Multidisciplinary Sciences

IgA transcytosis and antigen recognition govern ovarian cancer immunity

Subir Biswas et al.

Summary: Most ovarian cancers are infiltrated by activated T cells that have prognostic relevance, but they show low response rates to immune checkpoint inhibitors. On the contrary, memory B cell and plasma cell infiltrates associated with better outcomes may exert protective effects against tumor cells through B cell-derived IgA in ovarian cancer.

NATURE (2021)

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Article Cell Biology

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Jennifer A. Lo et al.

Summary: Studies suggest that patients responding to immune checkpoint inhibitors typically have higher levels of tumor-specific neoantigens and higher expression of pigmentation-related genes in tumors. Expansion of CD8(+) T cells specific for melanocyte antigens was observed only in patients responding to anti-PD-1 therapy, indicating potential breakdown of tolerance toward tumor-lineage self-antigens. Epitope spreading toward wild-type tumor-lineage self-antigens represents a common pathway for successful response to ICI.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Oncology

STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment

Manoj Chelvanambi et al.

Summary: The activation of STING within the TME leads to slowed melanoma growth, increased production of antiangiogenic and TLS-inducing factors, as well as improved VN and enhanced tumor infiltration by immune cells. The delivery of low-dose STING agonist promotes a proinflammatory TME supportive of TLS formation and tumor growth control.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Immunology

Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity

Yuzi Li et al.

Summary: DN B cells, a neglected memory B cell subset, have been shown to play important roles in various diseases, especially autoimmune diseases, based on recent studies.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Augmented antibody-based anticancer therapeutics boost neutrophil cytotoxicity

Niels Heemskerk et al.

Summary: The study created TrisomAb molecules that combined the agonistic activity of IgG mAbs and Fc?RI targeting in a therapeutic bispecific antibody format, recruiting multiple effector cells including NK cells, macrophages, and neutrophils for effective eradication of tumor cells. TrisomAb also showed long in vivo half-life and significantly decreased tumor outgrowth in mice, offering potential alternatives for cancer patients who do not benefit from current IgG mAb therapy.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Multidisciplinary Sciences

Diverse functional autoantibodies in patients with COVID-19

Eric Y. Wang et al.

Summary: COVID-19 patients show increased autoantibody reactivities against immunomodulatory proteins, which may affect immune function and lead to different clinical outcomes.

NATURE (2021)

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Article Oncology

Beneficial autoimmunity improves cancer prognosis

Laurence Zitvogel et al.

Nature Reviews Clinical Oncology (2021)

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Article Oncology

Tumor-Associated Neutrophils Drive B-cell Recruitment and Their Differentiation to Plasma Cells

Merav E. Shaul et al.

Summary: The study suggests that tumor-associated neutrophils play a crucial role in recruiting and modulating B cells into plasma cells in the tumor microenvironment, thereby opening new avenues in cancer immunotherapy targeting strategies.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Immunology

Single-Cell Transcriptomic Analyses Define Distinct Peripheral B Cell Subsets and Discrete Development Pathways

Alexander Stewart et al.

Summary: The separation of B cells into different subsets has provided insights into their diverse functions in immune responses. Advances in single-cell techniques have enabled a deeper understanding of B cell characteristics and functions, though challenges remain. This study offers a reference single-cell dataset for better classification of functional B cell subsets in peripheral blood, highlighting the complexity and diversity of B cell populations.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

The Potential of Harnessing IL-2-Mediated Immunosuppression to Prevent Pathogenic B Cell Responses

Amber Papillion et al.

Summary: Novel immunotherapies such as subcutaneous low-dose r-IL2 have shown potent immunosuppressive effects in autoimmune patients, particularly on Treg cells. Additionally, rIL-2 can directly inhibit other immune cells, potentially leading to a more efficient inhibition of auto-antibody production in autoimmune patients when combined with other cytokine-based therapies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

Jan C. Brase et al.

Summary: Although patients with unresectable or metastatic melanoma can experience long-term survival with targeted therapies, resistance is common and pretherapeutic biomarkers are lacking. A study on previously untreated BRAF V600-mutant melanoma patients treated with dabrafenib plus trametinib found that baseline cell-cycle gene expression signature and T-cell/B-cell gene signatures were associated with clinical outcomes, highlighting the potential predictive role of B cells in treatment response. Further validation in larger patient cohorts is needed to confirm these findings.

CLINICAL CANCER RESEARCH (2021)

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Review Immunology

CD4+T cells that help B cells - a proposal for uniform nomenclature

Stephanie C. Eisenbarth et al.

Summary: Tfh and Tfh-like cells guide B cell differentiation in secondary lymphoid tissues, playing essential roles in humoral immunity. They produce diverse combinations of cytokines and chemokine receptors to promote the generation of antibodies with different properties.

TRENDS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Luuk van Hooren et al.

Summary: This study demonstrates that the use of immunostimulatory CD40 antibodies in glioma models promotes the formation of tertiary lymphoid structures but does not improve survival and impairs the response to immune checkpoint blockade.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Ayana T. Ruffin et al.

Summary: The study suggests that enhancing TIL-B responses in HNSCC, particularly in HPV+ cases, could complement current T cell immunotherapies. The presence of tumor infiltrating B cells with GCs in TLS is associated with better survival outcomes in head and neck squamous cell carcinoma patients.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

Anthony B. Rodriguez et al.

Summary: The study reveals that the development of tumor-associated tertiary lymphoid structures (TA-TLS) is orchestrated by cancer-associated fibroblasts (CAF) with characteristics of lymphoid tissue organizer cells, mediated by CD8 T cells and CXCL13-mediated recruitment of B cells. The presence and size of TA-TLS are correlated with reduced tumor size and overall response to checkpoint immunotherapy, providing a potential platform for cancer immunotherapy strategy.

CELL REPORTS (2021)

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Article Oncology

CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses

Kerstin Wennhold et al.

Summary: The study found that BAPCs were increased in the tumor microenvironment of various cancer types, especially in patients with colorectal cancer and gastroesophageal adenocarcinoma. BAPCs were localized in lymphoid follicles of TLS, inducing autologous T-cell responses, which provides a mechanistic rationale for the correlation between B-cell abundance and response to immune checkpoint inhibition.

CANCER IMMUNOLOGY RESEARCH (2021)

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Review Immunology

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Charlotte Domblides et al.

Summary: The tumor microenvironment is unique to each patient and therapies targeting tumor cells or immune cells have limited long-term benefits. Hot tumors play a role in selecting therapies targeting patient immunity, with the presence of TLS associated with better survival and predicted response to ICP inhibitors. Increasing understanding of TLS biology may improve prognostic prediction and treatment selection for cancer patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma

Kevin T. Lynch et al.

Summary: The presence of TLS in cutaneous melanoma metastases is associated with increased intratumoral lymphocyte infiltration and improved overall survival in patients. Different types of TLS have varying effects on patient survival, indicating potential regulatory or antigen-driven immune responses.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Cell Biology

B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication

Gabriela Sarti Kinker et al.

Summary: B cells in the tumor microenvironment play diverse roles in modulating anti-tumor immune responses, especially within TLS formed during lymphoid neogenesis. The interaction between B cells and antigen-experienced and exhausted CD8(+) T cells is associated with improved response to immune checkpoint blockade in certain types of tumors. Conversely, the distribution and organization of B cells in the tumor microenvironment may lead to immune-regulatory functions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity

Gregory Noel et al.

Summary: This study found that T follicular helper (Tfh) cells in breast cancer play a key role in the formation of tertiary lymphoid structures (TLS), with active and functional Tfh TILs in TLS being associated with positive clinical outcomes in patients. The balance between functional Tfh TILs and functional T follicular regulatory (Tfr) TILs dictates the activity of tumor-associated TLS.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression

Lucile Vanhersecke et al.

Summary: The presence of mature tertiary lymphoid structures is associated with improved response to immunotherapy in cancer patients, predicting objective response rates, progression-free survival, and overall survival. These findings support the potential use of TLS detection to select patients who are more likely to benefit from immune checkpoint blockade.

NATURE CANCER (2021)

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Article Cell Biology

Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics

Susan Olalekan et al.

Summary: Understanding the cellular composition and interactions within the tumor microenvironment is crucial for successful cancer immunotherapies. By performing single-cell RNA sequencing of cells from six ovarian cancer patients, we identified nine major cell types and stratified immune cells into high T cell infiltration and low T cell infiltration groups. The study provides important insights into the immune response in ovarian tumors, highlighting potential anti-tumor responses in the high T cell infiltration group.

CELL REPORTS (2021)

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Article Oncology

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Andrew J. Gunderson et al.

Summary: PDAC tumors show T cell inflamed phenotypes, with some tumors having early-stage TLS which correlates with higher survival rates.

ONCOIMMUNOLOGY (2021)

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Review Oncology

Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Suchit Jhunjhunwala et al.

Summary: This review discusses the importance of antigen presentation in the success of immune checkpoint inhibition therapy and mechanisms by which tumors evade immune recognition. Tumors evade immune recognition by modulating antigen expression and altering antigen presentation.

NATURE REVIEWS CANCER (2021)

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CD40 Agonist Antibodies in Cancer Immunotherapy

Robert H. Vonderheide

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

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Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

Anthony R. Cillo et al.

IMMUNITY (2020)

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B cells are associated with survival and immunotherapy response in sarcoma

Florent Petitprez et al.

NATURE (2020)

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Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

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B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

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Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

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A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

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APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structures

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PD-1-expressing B cells suppress CD4+ and CD8+ T cells via PD-1/PD-L1-dependent pathway

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Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer

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Discrepancies in the Tumor Microenvironment of Spontaneous and Orthotopic Murine Models of Pancreatic Cancer Uncover a New Immunostimulatory Phenotype for B Cells

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Context-dependent roles of complement in cancer

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Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

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Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)

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A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

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Phenotype molding of stromal cells in the lung tumor microenvironment

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Self-Reactive B Cells in the Germinal Center Reaction

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Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

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Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

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Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

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Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer

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Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

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Germinal Centers Determine the Prognostic Relevance of Tertiary Lymphoid Structures and Are Impaired by Corticosteroids in Lung Squamous Cell Carcinoma

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Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression

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Neoadjuvant Chemotherapy of Ovarian Cancer Results in Three Patterns of Tumor-Infiltrating Lymphocyte Response with Distinct Implications for Immunotherapy

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CD40-activated B cells induce anti-tumor immunity in vivo

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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

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TRIM21 and the Function of Antibodies inside Cells

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Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

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Antigen-Presenting Intratumoral B Cells Affect CD4+ TIL Phenotypes in Non-Small Cell Lung Cancer Patients

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Using Antigen-Specific B Cells to Combine Antibody and T Cell-Based Cancer Immunotherapy

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De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors

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xCell: digitally portraying the tissue cellular heterogeneity landscape

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Cytoskeletal control of B cell responses to antigens

Pavel Tolar

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CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

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Doxorubicin enhances the capacity of B cells to activate T cells in urothelial urinary bladder cancer

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Autoantibodies: Opportunities for Early Cancer Detection

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NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers

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The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

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Interleukin 10-expressing B cells inhibit tumor-infiltrating T cell function and correlate with T cell Tim-3 expression in renal cell carcinoma

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PD-L1 mediated the differentiation of tumor-infiltrating CD19+ B lymphocytes and T cells in Invasive breast cancer

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Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

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Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer

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PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer

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A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

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CD19+IL-10+ regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4+ T cells to CD4+Foxp3+ regulatory T cells

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PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression

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How Follicular Dendritic Cells Shape the B-Cell Antigenome

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Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway

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Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10

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Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

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Regulatory B Cells: Origin, Phenotype, and Function

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IMMUNITY (2015)

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CD4+ T Cell-Derived IL-21 and Deprivation of CD40 Signaling Favor the In Vivo Development of Granzyme B-Expressing Regulatory B Cells in HIV Patients

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B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

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CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer

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Emerging and novel functions of complement protein C1 q

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Antibody-independent functions of B cells: a focus on cytokines

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Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

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Tissue-Resident Memory T Cells

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IMMUNITY (2014)

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Interleukin-35 induces regulatory B cells that suppress autoimmune disease

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Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

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Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

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SCIENCE TRANSLATIONAL MEDICINE (2014)

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Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

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CANCER IMMUNOLOGY RESEARCH (2014)

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Serologic Autoantibodies as Diagnostic Cancer Biomarkers-A Review

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Interleukin 21-Induced Granzyme B-Expressing B Cells Infiltrate Tumors and Regulate T Cells

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Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein

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MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

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Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator-Activated Receptor α

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Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells

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CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27- Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer

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Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

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IMMUNOLOGY AND CELL BIOLOGY (2012)

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Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

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A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

Masanori Matsumoto et al.

IMMUNITY (2011)

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Article Cell Biology

CD40-activated B cells contribute to mesothelioma tumor regression

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IMMUNOLOGY AND CELL BIOLOGY (2011)

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Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis

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Tumor Antigen-Targeted, Monoclonal Antibody-Based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape

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JOURNAL OF CLINICAL ONCOLOGY (2010)

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Article Immunology

Cryptic Epitopes Induce High-Titer Humoral Immune Response in Patients with Cancer

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JOURNAL OF IMMUNOLOGY (2010)

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B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

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NATURE (2010)

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Review Oncology

A systematic review of humoral immune responses against tumor antigens

Miriam Reuschenbach et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2009)

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Molecular mechanism and function of CD40/CD40L engagement in the immune system

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IMMUNOLOGICAL REVIEWS (2009)

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Killer B lymphocytes: the evidence and the potential

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INFLAMMATION RESEARCH (2009)

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Tumor-infiltrating B lymphocytes as an efficient source of highly specific immunoglobulins recognizing tumor cells

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BMC BIOTECHNOLOGY (2007)

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Article Immunology

Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis

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JOURNAL OF IMMUNOLOGY (2007)

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Meeting Abstract Oncology

Phase 1, pharmacokinetic (PK) and pharmacodynamic (PD) study of oral alvespimycin (A; KOS-1022; 17-DMAG): Two different schedules in patients with advanced malignancies

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Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody

Robert H. Vonderheide et al.

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Autoantibody signatures in prostate cancer

XJ Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Novel ganglioside antigen identified by B cells in human medullary breast carcinomas: The proof of principle concerning the tumor-infiltrating B lymphocytes

B Kotlan et al.

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Article Immunology

Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma

ES Doubrovina et al.

JOURNAL OF IMMUNOLOGY (2003)

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Predominant autoantibody production by early human B cell precursors

H Wardemann et al.

SCIENCE (2003)

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Titration of serum p53 antibodies in 1085 patients with various types of malignant tumors -: A multiinstitutional analysis by the Japan p53 Antibody Research Group

H Shimada et al.

CANCER (2003)

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Article Immunology

Role of B cells as antigen-presenting cells in vivo revisited:: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations

A Rivera et al.

INTERNATIONAL IMMUNOLOGY (2001)

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Article Multidisciplinary Sciences

The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells

MH Hansen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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