4.8 Article

Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Immunology

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

Yongyan Chen et al.

Summary: The liver is a lymphoid organ with unique immunological properties, and the balance between immune tolerance and immune activity is crucial for its physiological functions and sensitivity to diseases. Research on hepatic innate lymphocytes, including NK cells, ILC1/2/3s, NKT cells, gamma delta T cells, and MAIT cells, has become a focus, providing insights into their roles in liver homeostasis maintenance and disease progression. Understanding the immunopathogenesis of hepatic innate lymphocytes may lead to more effective treatments for liver diseases and cancer.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

Identification of human cytotoxic ILC3s

Lisette Krabbendam et al.

Summary: A previously unrecognized subset of ILCs in humans, characterized by CD94 expression, was identified to have high cytotoxicity similar to ILC3s but distinct from classical NK cells. These CD94(+) ILCs were not induced to differentiate into NK cells by IL-15, but maintained certain marker expressions and produced IL-22 in response to IL-15. Furthermore, non-cytotoxic ILC3s could upregulate CD94 and exhibit cytotoxic activity when cultured with IL-12, which was not observed with IL-15 stimulation.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

CD127+CD94+innate lymphoid cells expressing granulysin and perforin are expanded in patients with Crohn's disease

L. Krabbendam et al.

Summary: The study identifies two populations of CD127+CD94+ ILCs in the intestinal lamina propria, designated as population A and B, with population B expressing granulysin. Granulysin-expressing effector CD127+CD94+ ILCs are shown to be expanded in patients with Crohn's disease. The overlapping phenotypic markers between ILC1 and NK populations have impacted the specific analysis of these immune cell populations.

NATURE COMMUNICATIONS (2021)

Article Immunology

Gut Bacteria Induce Granzyme B Expression in Human Colonic ILC3s In Vitro in an IL-15-Dependent Manner

Moriah J. Castleman et al.

Summary: The study reveals that human colonic ILC3s can express granzyme B in response to a subset of enteric bacteria through a process mediated by IL-15. This finding raises new questions about the multifunctional role of human gut ILC3s.

JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

KLRG1 and NKp46 discriminate subpopulations of human CD117+CRTH2- ILCs biased toward ILC2 or ILC3

Maho Nagasawa et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Immunology

NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing

Isabel Prager et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Immunology

Deciphering the Roles of Innate Lymphoid Cells in Cancer

Melanie Bruchard et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cell Biology

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

Juming Yan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Lymphoid tissue inducer-A divergent member of the ILC family

Chao Zhong et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

Article Immunology

Tissue microenvironment dictates the fate and tumorsuppressive function of type 3 ILCs

Kathrin Nussbaum et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

Orr-El Weizman et al.

Article Biochemistry & Molecular Biology

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation

Ai Ing Lim et al.

Article Immunology

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

Ai Ing Lim et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Multidisciplinary Sciences

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Georg Gasteiger et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

Paolo Carrega et al.

NATURE COMMUNICATIONS (2015)

Article Immunology

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

Stefanie Kirchberger et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Immunology

Human type 1 innate lymphoid cells accumulate in inflamed mucosa! tissues

Jochem H. Bernink et al.

NATURE IMMUNOLOGY (2013)

Editorial Material Immunology

Type 2 innate lymphoid cells-new members of the type 2 franchise that mediate allergic airway inflammation

Jenny Mjosberg et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

Article Multidisciplinary Sciences

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Samuel Huber et al.

NATURE (2012)

Article Gastroenterology & Hepatology

Interleukin-22 Promotes Human Hepatocellular Carcinoma by Activation of STAT3

Runqiu Jiang et al.

HEPATOLOGY (2011)

Review Gastroenterology & Hepatology

On the TRAIL to therapeutic intervention in liver disease

Ingrid Herr et al.

HEPATOLOGY (2007)

Article Biochemistry & Molecular Biology

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

MS Buzza et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)