4.5 Review

Intestinal microbiota research from a global perspective

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Factors Associated with Stunted Growth in Children Under Five Years in Antananarivo, Madagascar and Bangui, Central African Republic

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Summary: Our study found that maternal education, limited access to hygiene products, anemia, and low birth weight were associated with an increased risk of stunting. In Antananarivo, factors such as short maternal stature, household head not being the parents, diarrhea, and coughing were associated with a higher risk of stunting, while continuing breastfeeding was linked to a lower risk. In Bangui, previous severe undernutrition and skin infections were associated with a higher risk, while changes in diet during pregnancy were linked to a lower risk of stunting. Overall, the results suggest the importance of maternal education, antenatal care, iron supplementation, hygiene interventions, breastfeeding promotion (Antananarivo), and improved nutrition (Bangui) in combating stunting.

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Ingrid S. Surono et al.

Summary: The study aimed to investigate the difference in gut microbiota composition between stunted Indonesian children and children with normal nutritional status, revealing significantly lower levels of Prevotella 9 in stunted children. It also found differences in the relative abundance of Bacteroidetes and Firmicutes between the two groups. Additionally, stunted children had lower macronutrient intake and potentially higher energy loss in the form of short-chain fatty acids and branched-chain fatty acids.

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Modeling transfer of vaginal microbiota from mother to infant in early life

Martin Steen Mortensen et al.

Summary: Early-life microbiota, particularly maternal vaginal microbiota, plays a crucial role in shaping the child's microbiota and influencing disease risk. Analysis of mother-child dyads revealed specific bacterial orders that demonstrate persistent or transient transfer patterns from the maternal vaginal microbiome, as well as common reservoir orders shared at later time points regardless of delivery mode.
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Ana Sofia Ribeiro Duarte et al.

Summary: Metagenomics can reveal the genetic content of microbiota in different environments, with great potential for investigating the transmission of foodborne hazards. This study demonstrates the application of metagenomics in attributing antimicrobial resistance sources, showing a potential relationship between fecal resistome components and specific reservoirs.

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Crossing Kingdoms: How the Mycobiota and Fungal-Bacterial Interactions Impact Host Health and Disease

William Santus et al.

Summary: Research has shown that the microbiota includes not only bacteria, but also fungi, viruses, and archaea. The commensal fungal community, or mycobiota, plays a significant role in host health and is associated with pathological conditions like inflammatory bowel disease. Therefore, studying the mycobiota is crucial for a comprehensive understanding of host-microbe interactions.

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Nonnutritive sweeteners can promote the dissemination of antibiotic resistance through conjugative gene transfer

Zhigang Yu et al.

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ISME JOURNAL (2021)

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Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization

Atara Uzan-Yulzari et al.

Summary: Exposure to antibiotics in the neonatal period may affect growth development in boys but not girls, while antibiotic use later in childhood is associated with increased body mass index. Additionally, neonatal antibiotic exposure has long-term effects on gut microbiome, leading to growth impairment in boys during the first six years of life.

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Role of Human Milk Bioactives on Infants' Gut and Immune Health

Laura E. Carr et al.

Summary: Exclusive human milk feeding for the first 6 months is vital for optimal health outcomes in newborns, while adding HMOs to infant formula could enhance defense mechanisms. Current research has shown important knowledge about HMOs, milk microbiota, immunoglobulins, lactoferrin, and milk miRNAs, but there are still gaps in understanding the roles and interactions of different milk components.

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Elevated rates of horizontal gene transfer in the industrialized human microbiome

Mathieu Groussin et al.

Summary: Industrialization has significant impacts on gene transfer in human gut bacteria, with higher rates of horizontal gene transfer (HGT) associated with industrialized lifestyles. This suggests that gut bacteria continuously acquire new functionality based on host lifestyle changes.
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Towards a mechanistic understanding of reciprocal drug-microbiome interactions

Michael Zimmermann et al.

Summary: Broad-spectrum antibiotics and non-antibiotic drugs can impact the human microbiome, with bidirectional interactions between microbes and drugs potentially affecting drug efficacy and microbial resistance. Recent studies have begun to uncover the extensive capacity of gut microbes to metabolize drugs, highlighting the need for further research into these interactions in drug discovery and precision medicine.

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The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

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Summary: In 2019, ISAPP convened a panel of experts to review the definition and scope of postbiotics. The panel defined postbiotics as a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host. This definition aims to provide common ground for future activities in this area.

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A Microbiota-Directed Food Intervention for Undernourished Children

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Summary: The study found that providing a microbiota-directed complementary food prototype (MDCF-2) to children with moderate acute malnutrition in Bangladeshi slums showed positive effects on growth, particularly in weight-for-length and weight-for-age z scores, with changes in plasma proteins related to bone growth and neurodevelopment. These findings suggest that targeted manipulation of microbiota components may be linked to growth outcomes in children with moderate acute malnutrition.

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Effects of domestication on the gut microbiota parallel those of human industrialization

Aspen T. Reese et al.

Summary: The study found that domestication and industrialization have had similar impacts on gut microbiota, mainly through changes in diet and ecological environment. Successfully re-establishing wild-like microbiota in domesticated mice through experiments demonstrates the potential for reshaping gut microbiota in domesticated animals.
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Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

Hyo Shin Yoon et al.

Summary: The study demonstrates that Akkermansia muciniphila increases thermogenesis and GLP-1 secretion in mice by inducing uncoupling protein 1. A protein secreted by A. muciniphila, P9, interacts with ICAM-2 and can target metabolic diseases. This interaction could be a potential therapeutic target for such diseases.

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Summary: The use of bacteriocins shows promise in various fields and continues to advance knowledge for therapeutic and food preservative applications. Research focuses on the mechanism, structure, and potential signaling modulation of bacteriocins in host-associated microbial communities.

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Nasal microbiota composition dynamics after occupational change in animal farmers suggest major shifts

Julia G. Kraemer et al.

Summary: Previous studies have shown higher diversity in the nasal microbiota of pig farmers compared to those with no farm animal contact. After leaving the pig farm, the diversity of nasal microbiota significantly decreases, and the microbiota composition of ex-pig farmers is more similar to cow farmers and non-exposed individuals than during their time working with pigs.

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Summary: This review discusses the impact of diet on gut microbiota and how it relates to childhood malnutrition. Diarrhoea, induced by pathogenic elements of the gut microbiota, contributes to malnutrition by leading to malabsorption of essential nutrients. The gut microbiota of severely malnourished children shows differences compared to healthy children, indicating a potential link between gut microbiota and malnutrition in children.

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Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural Zimbabwe.

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Oral administration of maternal vaginal microbes at birth to restore gut microbiome development in infants born by caesarean section: A pilot randomised placebo-controlled trial

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Summary: Oral administration of maternal vaginal microbiota did not alter gut microbiome development in infants born by caesarean section; limited colonisation of maternal vaginal strains suggests other maternal sources, such as the perianal area, may play a larger role in seeding the neonatal gut microbiome.

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Maternal prenatal gut microbiota composition predicts child behaviour

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Gut microbiota dysbiosis contributes to the development of chronic obstructive pulmonary disease

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Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

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Mark Woolhouse et al.

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