期刊
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
卷 6, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1002/rth2.12666
关键词
COVID-19; incidence; review; therapeutics; venous thromboembolism
资金
- Centers for Disease Control and Prevention [02-21-8813]
This article reviews the mechanisms of coagulopathy associated with COVID-19 and the epidemiology and pathophysiology of venous thromboembolism in patients. It also provides updated strategies for the prevention and treatment of VTE associated with SARS-CoV-2 infection.
COVID-19 (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) is associated with coagulopathy through numerous mechanisms. The reported incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19 has varied widely, and several meta-analyses have been performed to assess the overall prevalence of VTE. The novelty of this coronavirus strain along with its unique mechanisms for microvascular and macrovascular thrombosis has led to uncertainty as to how to diagnose, prevent, and treat thrombosis in patients affected by this virus. This review discusses the epidemiology and pathophysiology of thrombosis in the setting of SARS-CoV-2 infection along with an updated review on the preventative and treatment strategies for VTE associated with SARS-CoV-2 infection.
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