期刊
CHEMICAL SCIENCE
卷 13, 期 17, 页码 4930-4935出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc00487a
关键词
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资金
- NSFC [21971101, 22171127, 21801126]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011976]
- Department of Education of Guangdong Province [2021KTSCX106]
- Pearl River Talent Recruitment Program [2019QN01Y261]
- Stable Support Plan Program of Shenzhen Natural Science Fund [20200925152608001]
- Thousand Talents Program for Young Scholars, Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
In this study, we report a simple and practical method for the alkylalation of alkenes using a nickel catalyst. Two different alkyl bromides were used as substrates to obtain alkenes with two aliphatic substituents at room temperature.
Among the carbo-difunctionalization of alkynes, the stereoselective dialkylation of alkynes is the most challenging transformation due to associated competitive side reactions and thus remains underdeveloped. Herein, we report the first Ni-catalyzed regio- and trans-selective cross-dialkylation of alkynes with two distinct alkyl bromides to afford olefins with two aliphatic substituents. The reductive conditions circumvent the use of organometallic reagents, enabling the cross-dialkylation process to occur at room temperature from two different alkyl bromides. This operationally simple protocol provides a straightforward and practical access to a wide range of stereodefined dialkylated olefins with broad functional group tolerance from easily available starting materials.
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