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Emerging roles of lncRNA in Nasopharyngeal Carcinoma and therapeutic opportunities

期刊

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 7, 页码 2714-2728

出版社

IVYSPRING INT PUBL
DOI: 10.7150/ijbs.70292

关键词

Long-non-coding RNAs; Nasopharyngeal Carcinoma; emerging roles; therapeutic opportunities

资金

  1. National Nature Science Foundation of China [81773218, 81972838, 81802791]
  2. Natural Science Foundation of Hunan Province [2020JJ4122]

向作者/读者索取更多资源

Nasopharyngeal carcinoma is a malignant tumor with specific ethnic and geographical distribution characteristics. Recent studies have shown that long non-coding RNAs play important regulatory roles in the development of nasopharyngeal carcinoma. In-depth understanding of abnormal lncRNAs may provide new insights into the pathogenesis of nasopharyngeal carcinoma and offer new approaches for early diagnosis and treatment.
Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor with ethnic and geographical distribution characteristics. However, the molecular mechanisms of NPC are still unclear. Long non encoding RNAs (lncRNAs) are becoming important regulators in gene expression networks, including post transcriptional and post translational regulation of protein, protein complex organization, signal transduction and recombination among cells, which are involved in cancer recognition. Recent evidence shows that lncRNAs play important roles in the occurrence and development of NPC. Therefore, in-depth understanding of abnormal lncRNAs will provide new understanding of the pathogenesis in NPC, and provide new tools for the early diagnosis and treatment of NPC. This article reviews the abnormal lncRNAs in NPC cells and the roles of lncRNAs in the tumorigenesis of NPC. In addition, we also discuss the diagnostic and therapeutic potential of lncRNAs in NPC.

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