期刊
INFECTION AND CHEMOTHERAPY
卷 54, 期 1, 页码 80-90出版社
KOREAN SOC ANTIMICROBIAL THERAPY
DOI: 10.3947/ic.2021.0126
关键词
Febrile neutropenia; Pneumonia; Hematologic malignancy; Methicillin-resistant Staphylococcus aureus; Staphylococcal infection
The study demonstrates that ABK is effective and safe in treating patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. It may also be effective in patients who do not respond to other anti-MRSA drugs. Therefore, ABK could be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN.
Background: Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused by MRSA, ABK may be sufficiently effective even as a single agent. Materials and Methods: Patients with hematologic malignancies treated with ABK who met the following criteria were included: 1) fever during neutropenia or functional neutropenia, 2) FN complicated by pneumonia, and 3) possible infection by antimicrobial-resistant Gram-positive cocci. Results: This study encompassed 22 episodes involving 19 patients, of which, 15 (68.2%) were successfully treated with ABK. Of the nine episodes showing inadequate response to other anti-MRSA drugs, eight were successfully treated with ABK. Grade 2 or worse adverse events included acute kidney injury (13.6%) and increased transaminase levels (9.1%). Conclusion: The present study demonstrated that ABK is effective and safe in patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. ABK may also be effective in patients who are unresponsive to other anti-MRSA drugs. Therefore, ABK may be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN.
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