期刊
CLINICAL & TRANSLATIONAL IMMUNOLOGY
卷 11, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/cti2.1388
关键词
COVID-19; hybrid immunity; immune responses; SARS-CoV-2; vaccination
类别
资金
- Jonas & Christina af Jochnick Foundation
- Lundblad Family Foundation
- Region Stockholm
- Knut and Alice Wallenberg Foundation
- Science for Life Laboratory
- Erling-Persson Family Foundation
- Center for Innovative Medicine
- Swedish Research Council
- Jonas Soderquist's scholarship
This study investigated the long-term impact of prior SARS-CoV-2 infection on immune responses after COVID-19 vaccination. The results showed that prior SARS-CoV-2 infection substantially enhanced T-cell responses, anti-spike IgG responses, and neutralising antibodies in vaccinated individuals. These findings suggest that prior infection should be considered when planning future COVID-19 vaccine programs.
Objective. To determine the long-term impact of prior SARS-CoV-2 infection on immune responses after COVID-19 vaccination. Methods. Using longitudinally collected blood samples from the COMMUNITY study, we determined binding (WHO BAU mL(-1)) and neutralising antibody titres against ten SARS-CoV-2 variants over 7 months following BNT162b2 in SARS-CoV-2-recovered (n = 118) and SARS-CoV-2-naive (n = 289) healthcare workers with confirmed prior SARS-CoV-2 infection. A smaller group with (n = 47) and without (n = 60) confirmed prior SARS-CoV-2 infection receiving ChAdOx1 nCoV-19 was followed for 3 months. SARS-CoV-2-specific memory T-cell responses were investigated in a subset of SARS-CoV-2-naive and SARS-CoV-2-recovered vaccinees. Results. Vaccination with both vaccine platforms resulted in substantially enhanced T-cell responses, anti-spike IgG responses and neutralising antibodies effective against ten SARS-CoV-2 variants in SARS-CoV-2-recovered participants as compared to SARS-CoV-2-naive participants. The enhanced immune responses sustained over 7 months following vaccination. Conclusion. These findings imply that prior SARS-CoV-2 infection should be taken into consideration when planning booster doses and design of current and future COVID-19 vaccine programmes.
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