☆ 3.8 Article

Physiological hormesis and hormetins in biogerontology

CURRENT OPINION IN TOXICOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Chemistry, Medicinal

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases

Alexander G. Panossian et al.

Summary: Adaptogens are herbal medicinal and nutritional products promoting adaptability and survival in living organisms. They have pharmacologically pleiotropic effects on the neuroendocrine-immune system and exhibit a biphasic dose-effect response. Further research focusing on discovering new combinations of adaptogens and potential synergistic effects is needed to explore their full potential in treating stress and aging-related diseases.

MEDICINAL RESEARCH REVIEWS (2021)

添加到收藏夹

Review Cell Biology

Metformin-enhances resilience via hormesis

Edward J. Calabrese et al.

Summary: Metformin induced hormetic biphasic dose responses across multiple organ systems and cell types, enhancing resilience to chemical stresses through an anti-inflammatory molecular network, thereby delaying the onset and progression of neurodegenerative and chronic diseases.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study

Ilya Pinchuk et al.

Summary: Redox steady state is crucial for cellular functions, while Oxidative Stress is associated with various pathologies. Understanding the relationship between oxidative stress biomarkers and antioxidants can help in selective treatment. The effects of different LMWA on oxidative damage biomarkers need to be carefully studied before justifying a single LMWA treatment approach.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Oxidative eustress: On constant alert for redox homeostasis

Helmut Sies

Summary: The spatiotemporal control of redox signaling in cells relies on continuous fine-tuning, with molecules like H2O2 playing a key role. Oxidative eustress operates within a specific physiological range, and is managed through both short-term and long-term homeostatic mechanisms to respond to stress.

REDOX BIOLOGY (2021)

添加到收藏夹

Review Nutrition & Dietetics

Mediterranean diet and the hallmarks of ageing

Oliver M. Shannon et al.

Summary: Ageing is a multifactorial process that involves reduced function and increased risk of diseases and death. Healthy dietary patterns can reduce the risk of age-related diseases and increase longevity by positively influencing cellular and molecular hallmarks of ageing. The Mediterranean dietary pattern, characterized by plant-based foods, has been associated with better health during ageing and may impact each hallmark of ageing positively.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2021)

添加到收藏夹

Review Multidisciplinary Sciences

Antiaging diets: Separating fact from fiction

Mitchell B. Lee et al.

Summary: Caloric restriction and other anti-aging diets can extend lifespan and delay age-related pathology. These diets offer new insights into the mechanisms of biological aging and potential clinical applications.

SCIENCE (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review

Anand Thirupathi et al.

Summary: Exercise-induced benefits in promoting health and preventing diseases are increasingly recognized, but different types and intensities of exercise may increase oxidative damage. The training status of the individual and specific oxidative damage markers play a crucial role in predicting oxidative damage. More follow-up programs with larger numbers are needed to confirm findings.

BIOMED RESEARCH INTERNATIONAL (2021)

添加到收藏夹

Review Cell Biology

The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis

Keenan A. Ramsey et al.

Summary: Higher levels of physical activity and reduced sedentary behavior in older adults are associated with better upper and lower body muscle strength and muscle power. These associations are particularly significant in the chair stand test.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Environmental Sciences

An update in toxicology of ageing

Lucia Rackova et al.

Summary: The field of ageing research has rapidly advanced, focusing on the impact of environmental factors on the pace of ageing in organisms. The research highlights the endogenous pathways accelerating ageing and the identification of biomarkers for ageing. A comprehensive overview of environmental gerontogens is provided, with a brief discussion on the hormetic and ageing decelerating effects of environmental factors.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

The hormetic dose-response mechanism: Nrf2 activation

Edward J. Calabrese et al.

Summary: Nrf2 serves as an adaptive mechanism that can be activated by various oxidative stressors, integrating and enhancing metabolic strategies to produce acquired resilience.

PHARMACOLOGICAL RESEARCH (2021)

添加到收藏夹

Article Behavioral Sciences

The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota

Giuseppe Annunziata et al.

Summary: Neurodegenerative disorders, especially in the elderly population, pose a significant social and healthcare challenge worldwide. Changes in immune response are closely linked to the development of these diseases, while alterations in gut microbiota composition may contribute to neuroinflammatory disorders. Polyphenols play a crucial role in exerting neuroprotective and immunomodulatory effects, potentially offering therapeutic applications in neurodegenerative diseases.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics

Donald K. Ingram et al.

Summary: Calorie restriction mimetics is a field aimed at developing treatments that mimic the anti-aging effects of long-term calorie restriction. Glycolytic inhibition is considered an effective strategy to activate anti-aging mechanisms. Various compounds are being studied for their potential anti-aging effects, with some showing promising results.

GEROSCIENCE (2021)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Naive extrapolations, overhyped claims and empty promises in ageing research and interventions need avoidance

Suresh I. S. Rattan

BIOGERONTOLOGY (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy

Sergio Davinelli et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2020)

添加到收藏夹

Article Geriatrics & Gerontology

The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging

Elissa S. Epel

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Review Plant Sciences

Hormesis: Highly Generalizable and Beyond Laboratory

Evgenios Agathokleous et al.

TRENDS IN PLANT SCIENCE (2020)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

Modulating gut microbes Fecal microbiota transplant and modulation of microbial species show therapeutic promise

Jennifer A. Wargo

SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Relationship between Diet, Microbiota, and Healthy Aging

Elisa Sanchez-Morate et al.

BIOMEDICINES (2020)

添加到收藏夹

Review Nutrition & Dietetics

Nutrition Can Help DNA Repair in the Case of Aging

Julia Kazmierczak-Baranska et al.

NUTRIENTS (2020)

添加到收藏夹

Review Cell Biology

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Frank Madeo et al.

CELL METABOLISM (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

Huib H. Rabouw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Review Physiology

The Panacea of Human Aging: Calorie Restriction Versus Exercise

Nicholas T. Broskey et al.

EXERCISE AND SPORT SCIENCES REVIEWS (2019)

添加到收藏夹

Article Genetics & Heredity

The Microbiome and Aging

Bianca Bana et al.

Annual Review of Genetics (2019)

添加到收藏夹

Article Cell Biology

Rapamycin for longevity: opinion article

Mikhail V. Blagosklonny

AGING-US (2019)

添加到收藏夹

Review Cell Biology

mTOR as a central hub of nutrient signalling and cell growth

Joungmok Kim et al.

NATURE CELL BIOLOGY (2019)

添加到收藏夹

Article Cell Biology

A preliminary attempt to establish multiple stress response profiles of human skin fibroblasts exposed to mild or severe stress during ageing in vitro

Suresh I. S. Rattan et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine

Dali Wang et al.

PHARMACOLOGY & THERAPEUTICS (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Enhancing and Extending Biological Performance and Resilience

Rehana K. Leak et al.

DOSE-RESPONSE (2018)

添加到收藏夹

Article Cell Biology

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

Johnathan Labbadia et al.

CELL REPORTS (2017)

添加到收藏夹

Review Geriatrics & Gerontology

AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms

Antero Salminen et al.

BIOGERONTOLOGY (2016)

添加到收藏夹

Article Geriatrics & Gerontology

Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis

Dino Demirovic et al.

EXPERIMENTAL GERONTOLOGY (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Edward J. Calabrese et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.