相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Endothelial-to-Mesenchymal Transition An Evolving Paradigm and a Promising Therapeutic Target in PAH
Kurt R. Stenmark et al.
CIRCULATION (2016)
In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug
Rachel K. Hopper et al.
CIRCULATION (2016)
Pulmonary veno-occlusive disease
David Montani et al.
EUROPEAN RESPIRATORY JOURNAL (2016)
The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice
Pinelopi P. Kapitsinou et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
FOXO1 couples metabolic activity and growth state in the vascular endothelium
Kerstin Wilhelm et al.
NATURE (2016)
Bone Morphogenetic Protein Receptor Type II and Inflammation Are Bringing Old Concepts into the New Pulmonary Arterial Hypertension World
Frederic Perros et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)
Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production
Elaine Soon et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)
Notch Activation of Ca2+ Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension
Kimberly A. Smith et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)
Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension
Benoit Ranchoux et al.
CIRCULATION (2015)
Addressing Complexity in Pulmonary Hypertension The FoxO1 Case
Roxane Paulin et al.
CIRCULATION RESEARCH (2015)
Modulation of miRNAs in Pulmonary Hypertension
Sudhiranjan Gupta et al.
INTERNATIONAL JOURNAL OF HYPERTENSION (2015)
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
Katharina Bluemlein et al.
Oncotarget (2015)
Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
Jun-Dae Kim et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2015)
Restoration of Impaired Endothelial Myocyte Enhancer Factor 2 Function Rescues Pulmonary Arterial Hypertension
Jongmin Kim et al.
CIRCULATION (2015)
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells
Hisao Yamamura et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)
Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α
Molly K. Ball et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Novel and Emerging Therapies for Pulmonary Hypertension
Soni Savai Pullamsetti et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Endothelial Kruppel-Like Factor 4 Modulates Pulmonary Arterial Hypertension
Mohammad A. Shatat et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)
Dissecting histone deacetylase role in pulmonary arterial smooth muscle cell proliferation and migration
Margherita Galletti et al.
BIOCHEMICAL PHARMACOLOGY (2014)
The Metabolic Theory of Pulmonary Arterial Hypertension
Roxane Paulin et al.
CIRCULATION RESEARCH (2014)
MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts
Daren Wang et al.
CIRCULATION RESEARCH (2014)
Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent
Valentina Biasin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)
Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension
Karim C. El Kasmi et al.
JOURNAL OF IMMUNOLOGY (2014)
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
Rajkumar Savai et al.
NATURE MEDICINE (2014)
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
Maimon E. Hubbi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
Yuhui Jiang et al.
NATURE COMMUNICATIONS (2014)
Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers
Shruti Desai et al.
ONCOTARGET (2014)
STIM2 Contributes to Enhanced Store-Operated Ca2+ Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension
Michael Y. Song et al.
Pulmonary Circulation (2014)
Histone deacetylase inhibition with trichostatin A does not reverse severe angioproliferative pulmonary hypertension in rats (2013 Grover Conference series)
Michiel Alexander De Raaf et al.
PULMONARY CIRCULATION (2014)
Endothelial GATA-6 Deficiency Promotes Pulmonary Arterial Hypertension
Angela Ghatnekar et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Cytotoxic Cells and Granulysin in Pulmonary Arterial Hypertension and Pulmonary Veno-occlusive Disease
Frederic Perros et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)
Twist reverses muscle cell differentiation through transcriptional down-regulation of myogenin
Nikolaos P. Mastroyiannopoulos et al.
BIOSCIENCE REPORTS (2013)
Transcriptional Regulation and Its Misregulation in Disease
Tong Ihn Lee et al.
CELL (2013)
Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells
Q. Yang et al.
CELL PROLIFERATION (2013)
Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response
Matthew R. Pawlus et al.
CELLULAR SIGNALLING (2013)
Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition
Silvia Cantoni et al.
FEBS JOURNAL (2013)
FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate
Lin Piao et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2013)
Definitions and Diagnosis of Pulmonary Hypertension
Marius M. Hoeper et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension
Rubin M. Tuder et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)
Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Lei Lv et al.
MOLECULAR CELL (2013)
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension
Marine Germain et al.
NATURE GENETICS (2013)
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
Rachelle S. Doody et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Nuclear Factor κ-B Is Activated in the Pulmonary Vessels of Patients with End-Stage Idiopathic Pulmonary Arterial Hypertension
Laura C. Price et al.
PLOS ONE (2013)
Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer
Li-Jun Di et al.
NATURE COMMUNICATIONS (2013)
Disentangling the Many Layers of Eukaryotic Transcriptional Regulation
Katherine M. Lelli et al.
ANNUAL REVIEW OF GENETICS, VOL 46 (2012)
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
Weiwei Yang et al.
CELL (2012)
Histone Deacetylation Inhibition in Pulmonary Hypertension Therapeutic Potential of Valproic Acid and Suberoylanilide Hydroxamic Acid
Lan Zhao et al.
CIRCULATION (2012)
Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism
Maria A. Cavasin et al.
CIRCULATION RESEARCH (2012)
Enhanced Ca2+-Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura et al.
CIRCULATION RESEARCH (2012)
Enhancers: emerging roles in cell fate specification
Chin-Tong Ong et al.
EMBO REPORTS (2012)
Involvement of CtBP2 in LPS-induced microglial activation
Guowei Zhang et al.
JOURNAL OF MOLECULAR HISTOLOGY (2012)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang et al.
NATURE CELL BIOLOGY (2012)
Transcription factors: from enhancer binding to developmental control
Francois Spitz et al.
NATURE REVIEWS GENETICS (2012)
The co-regulation mechanism of transcription factors in the human gene regulatory network
Junil Kim et al.
NUCLEIC ACIDS RESEARCH (2012)
Histone H2A variants in nucleosomes and chromatin: more or less stable?
Clemens Boenisch et al.
NUCLEIC ACIDS RESEARCH (2012)
HYPOXIC PULMONARY VASOCONSTRICTION
J. T. Sylvester et al.
PHYSIOLOGICAL REVIEWS (2012)
PGC-1 alpha Induction in Pulmonary Arterial Hypertension
Manuel Mata et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2012)
Role of Transcriptional Corepressor CtBP1 in Prostate Cancer Progression
Rui Wang et al.
NEOPLASIA (2012)
Targeting the Adventitial Microenvironment in Pulmonary Hypertension: A Potential Approach to Therapy that Considers Epigenetic Change
Kurt R. Stenmark et al.
Pulmonary Circulation (2012)
Altered expression of nuclear and cytoplasmic histone H1 in pulmonary artery and pulmonary artery smooth muscle cells in patients with IPAH
Megha Talati et al.
Pulmonary Circulation (2012)
NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice
R. Bierer et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)
p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice
Shiro Mizuno et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)
Suppression of Histone Deacetylases Worsens Right Ventricular Dysfunction after Pulmonary Artery Banding in Rats
Harm J. Bogaard et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo et al.
CELL (2011)
Epigenetic regulation of pulmonary arterial hypertension
Xue-Feng Xu et al.
HYPERTENSION RESEARCH (2011)
Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension
Min Li et al.
JOURNAL OF IMMUNOLOGY (2011)
Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3β/β-catenin signaling in neonatal rats
Yan-ping Xu et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2011)
Phosphorylation of the Twist1-Family Basic Helix-Loop-Helix Transcription Factors Is Involved in Pathological Cardiac Remodeling
Shuangshuang Lu et al.
PLOS ONE (2011)
Transcription factor RBPJ/CSL: A genome-wide look at transcriptional regulation
Lucio Miele
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Applications of post-translational modifications of FoxO family proteins in biological functions
Ying Zhao et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2011)
Notch signalling in solid tumours: a little bit of everything but not all the time
Prathibha Ranganathan et al.
NATURE REVIEWS CANCER (2011)
Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
Amy L. Firth et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)
Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension A Basis for Excessive Cell Proliferation and a New Therapeutic Target
Stephen L. Archer et al.
CIRCULATION (2010)
Regulation of Vascularization by Hypoxia-Inducible Factor 1
Gregg L. Semenza
HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY (2009)
The Transcriptional Corepressor CtBP: A Foe of Multiple Tumor Suppressors
G. Chinnadurai
CANCER RESEARCH (2009)
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Raphael Kopan et al.
CELL (2009)
A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension
Ying Yu et al.
CIRCULATION (2009)
Methylated genes as new cancer biomarkers
M. J. Duffy et al.
EUROPEAN JOURNAL OF CANCER (2009)
Defective pulmonary vascular remodeling in Smad8 mutant mice
Zheng Huang et al.
HUMAN MOLECULAR GENETICS (2009)
Notch3 signaling promotes the development of pulmonary arterial hypertension
Xiaodong Li et al.
NATURE MEDICINE (2009)
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCζ in the pulmonary artery adventitia
Mita Das et al.
CARDIOVASCULAR RESEARCH (2008)
An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension
Georg Hansmann et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Chromatin opening and stable perturbation of core histone: DNA contacts by FoxO1
Mitsutoki Hatta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines
E. M. Hurt et al.
BRITISH JOURNAL OF CANCER (2007)
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
Fares A. Masri et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
Transcription coactivators for peroxisome proliferator-activated receptors
Songtao Yu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)
TRP channels in hypertension
Amy L. Firth et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)
The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
Sebastien Bonnet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension
Enrique Arciniegas et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)
Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling
Masanori Hayashi et al.
JOURNAL OF CELL SCIENCE (2007)
Basal transcription machinery: role in regulation of stress response in eukaryotes
Parag Sadhale et al.
JOURNAL OF BIOSCIENCES (2007)
Epigenetics: A landscape takes shape
Aaron D. Goldberg et al.
CELL (2007)
The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas
Cristina Pena et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
FOXOs in the maintenance of vascular homoeostasis
J-H Paik
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Hypoxia-induced pulmonary vascular remodeling - Cellular and molecular mechanisms
Kurt R. Stenmark et al.
CIRCULATION RESEARCH (2006)
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells
Jian Wang et al.
CIRCULATION RESEARCH (2006)
An abnormal mitochondrial-hypoxia inducible factor-1α-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats -: Similarities to human pulmonary arterial hypertension
Sébastien Bonnet et al.
CIRCULATION (2006)
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease
ER Siemers et al.
NEUROLOGY (2006)
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptionaf response
Michael G. Rosenfeld et al.
GENES & DEVELOPMENT (2006)
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
T Hosaka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells -: A novel mechanism of hypoxic pulmonary hypertension
MJ Lin et al.
CIRCULATION RESEARCH (2004)
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
B Altenberg et al.
GENOMICS (2004)
Peroxisome proliferator-activated receptor gamma (PPARγ) expression is decreased in pulmonary hypertension and affects endothelial cell growth
S Ameshima et al.
CIRCULATION RESEARCH (2003)
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs
M Grooteclaes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex
SF Zhou et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)