期刊
出版社
CEVAP-SAO PAULO STATE UNIV-UNESP
DOI: 10.1590/1678-9199-JVATITD-2021-0074
关键词
Coronavirus; SARS-CoV-2; Pets; Cats; Disease transmission
资金
- Brazilian National Council for Scientific and Technological Development (CNPq) [2020-1/402341]
This study found that viral antigens may be detected by immunohistochemistry in multiple organs six weeks after infection, despite negative results by RT-PCR testing.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation: We describe the pathological and molecular findings in a six-monthold asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. Conclusion: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.
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