Update on omicron variant: What we know so far

Editorial Material Infectious Diseases

Emergence of new SARS-CoV-2 Variant of Concern Omicron (B.1.1.529)-highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of vaccine distribution, inadequacies in global COVID-19 response and control efforts

Eskild Petersen et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Immunology

Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies

Saathvik R. Kannan et al.

Summary: The Omicron variant of concern (VOC) has a large number of mutations, with 46 high prevalence mutations, which may affect the binding affinities of antibodies to the S protein.

JOURNAL OF AUTOIMMUNITY (2022)

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Article Chemistry, Medicinal

Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance

Jiahui Chen et al.

Summary: The Omicron variant of the SARS-CoV-2 virus has caused global panic due to its high infectivity and ability to escape vaccines. A comprehensive analysis using an artificial intelligence model and antibody structure analysis reveals that Omicron may be over 10 times more contagious than the original virus and has an 88% likelihood of vaccine escape. This study highlights the importance of developing mutation-proof vaccines and antibodies.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)

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Article Virology

Omicron variant genome evolution and phylogenetics

Mahmoud Kandeel et al.

Summary: The study investigates the evolutionary relationships and similarities between the Omicron variant and other SARS-CoV-2 variants, finding that the Omicron variant forms a new monophyletic clade distant from other variants.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Letter Virology

Detection of highly muted coronavirus variant Omicron (B.1.1.529) is triggering the alarm for South Asian countries: Associated risk factors and preventive actions

Sohel Daria et al.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Article Virology

Characterization of the novel SARS-CoV-2 Omicron (B.1.1.529) variant of concern and its global perspective

Shailendra K. Saxena et al.

Summary: Omicron is the latest variant of concern of SARS-CoV-2, with more mutations compared to the previous Delta variant. Fifteen of these mutations are located in the receptor-binding domain of the spike glycoprotein, which may affect transmissibility, infectivity, antibody neutralization, and vaccine efficacy. The study provides insights into the mutational hotspots of Omicron and its global impact on transmission, testing, and immunity.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Editorial Material Virology

Omicron variant (B.1.1.529) of SARS-CoV-2, a global urgent public health alert!

Shou-Jiang Gao et al.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Editorial Material Anesthesiology

Omicron SARS-CoV-2 variant: What we know and what we don't

Valentine Marie Ferre et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2022)

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Review Anatomy & Morphology

Clinically relevant cell culture models and their significance in isolation, pathogenesis, vaccine development, repurposing and screening of new drugs for SARS-CoV-2: a systematic review

Subodh Kumar et al.

Summary: This study provides a detailed summary and evaluation of the most suitable cell lines for SARS-CoV-2 in vitro models, including cell culture-based studies and vaccine production, identifying the most widely used cell lines.

TISSUE & CELL (2021)

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News Item Multidisciplinary Sciences

OMICRON LIKELY TO WEAKEN COVID VACCINE PROTECTION

Ewen Callaway

NATURE (2021)

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Article Multidisciplinary Sciences

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants

Sebastian Weigang et al.

Summary: In a longitudinal case study, researchers demonstrate that SARS-CoV-2 variants with reduced sensitivity to neutralizing antibodies can evolve within persistently infected immunosuppressed patients. The study suggests that immunocompromised patients may serve as a potential source for the emergence of harmful variants, although immune control against these variants can still be achieved in some cases through the generation of neutralizing antibodies upon lowering immunosuppressive treatment.

NATURE COMMUNICATIONS (2021)

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Article Biochemical Research Methods

Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2

Manisha Prajapat et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2020)

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Update on omicron variant: What we know so far

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