期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 18, 页码 3675-3702出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00162d
关键词
-
资金
- National Science Foundation [OAC-1934725]
- Welch Foundation [23B571 (MF/ARB)]
The catalytic hydroboration of imines, nitriles, and carbodiimides is an important method for synthesizing key intermediates in the production of valuable products. The use of precious metals and harsh reaction conditions in initial studies has been replaced by the use of base metals, main group elements, and milder reaction conditions in recent advancements. This review categorizes the metal and nonmetal catalyzed hydroboration of these unsaturated organic molecules into precious metals, base metals, and main group catalysts, and provides a summary of the TON and TOF of imine hydroboration catalysts, as well as recent progress in the field.
The catalytic hydroboration of imines, nitriles, and carbodiimides is a powerful method of preparing amines which are key synthetic intermediates in the synthesis of many value-added products. Imine hydroboration has perennially featured in notable reports while nitrile and carbodiimide hydroboration have gained attention recently. Initial developments in catalytic hydroboration of imines and nitriles employed precious metals and typically required harsh reaction conditions. More recent advances have shifted toward the use of base metal and main group element catalysis and milder reaction conditions. In this survey, we review metal and nonmetal catalyzed hydroboration of these unsaturated organic molecules and group them into three distinct categories: precious metals, base metals, and main group catalysts. The TON and TOF of imine hydroboration catalysts are reported and summarized with a brief overview of recent advances in the field. Mechanistic and kinetic studies of some of these protocols are also presented.
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