Asymmetric synthesis of δ-substituted-β-keto esters and β-substituted ketones via carboxyl-assisted site- and enantio-selective addition reactions

Carboxyl-assisted site- and enantio-selective additions of polyfunctional nucleophiles to imines and carbonyls were developed, affording delta-substituted-beta-keto esters and beta-substituted ketones with good yields and enantioselectivities. Besides, short synthetic routes to bioactive molecules were also achieved.

Automated summary

A carboxyl-assisted reaction method has been developed for the site- and enantio-selective additions of polyfunctional nucleophiles to imines and carbonyls. This method provides efficient access to delta-substituted-beta-keto esters and beta-substituted ketones with good yields and enantioselectivities. Additionally, short synthetic routes to bioactive molecules have been achieved.