期刊
NANOTECHNOLOGY REVIEWS
卷 11, 期 1, 页码 1744-1777出版社
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/ntrev-2022-0109
关键词
lipid nanocarriers; nanostructured lipid carriers; optimization; novel drug delivery; statistical designs; quality by design
类别
资金
- Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia [ISP20-15]
This review summarizes the formulation development and optimization strategies for lipid-based colloidal carriers, particularly NLCs. The paper discusses various types of NLCs, formulation components, preparation methods, characterization parameters, optimization strategies, toxicity, regulatory aspects, as well as applications in different drug delivery routes.
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and significant entrants in the development of drug delivery systems owing to their myriad advantages. The NLCs are second-generation SLNs having unstructured matrix, have high drug loading, and provide long-term drug stability in comparison to SLNs and other colloidal systems, which show lower drug loading and experience burst release/drug expulsion during storage. This review is aimed to summarize the formulation development and optimization strategies for NLCs as reported in the literature collected from authentic databases. Various types of NLCs, formulation components, methods of preparation, characterization parameters, optimization (statistical designs) strategies, toxicity, regulatory aspects, and their applications in oral, parenteral, ocular, pulmonary, nose-to-brain, tumor targeting, and transdermal drug delivery have been dealt in detail. Patents granted on the NLCs have also been enlisted.
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