期刊
ORGANIC CHEMISTRY FRONTIERS
卷 9, 期 10, 页码 2786-2791出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00406b
关键词
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资金
- National Key R&D Program of China [2021YFA1500104]
- National Natural Science Foundation of China [22031008]
- Science Foundation of Wuhan [2020010601012192]
Organoselenium compounds are important in medicinal chemistry, materials chemistry, and biochemistry. The selenation of pharmaceutical molecules is a promising method for discovering new drugs. This study introduces an electrochemical oxidative radical cascade cyclization of olefinic amides and diselenides without the need for transition-metal catalysts and external oxidants, resulting in high yields of desired products.
Organoselenium compounds are important structures in medicinal chemistry, materials chemistry and biochemistry. Many drugs contain heterocyclic skeletons. The selenation of pharmaceutical molecules is a promising way to discover new drugs. Herein, we introduced an electrochemical oxidative radical cascade cyclization of olefinic amides and diselenides without transition-metal catalysts and external oxidants. Various olefinic amides and diselenides were compatible, generating the desired products, more than 40 examples, in up to 94% yield. This selenocyclization reaction provided a facile method to construct C-Se and C-O bonds in one step.
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