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Article
Medicine, General & Internal
D. Mevorach et al.
Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Adriana Luk et al.
Summary: The mRNA vaccines against COVID-19 have been effective in reducing symptomatic cases globally, but cases of vaccine-related myocarditis/pericarditis have been reported, especially in male adolescents and young adults with symptom onset typically within 1 week after vaccination. A clinical framework is highlighted to guide providers on assessing, investigating, diagnosing, and reporting suspected and confirmed cases, with recommended standardized workup and imaging modalities such as echocardiography for unexplained elevations in troponin. Treatment is supportive, and diagnosis based on defined clinical criteria should be reported to public health authorities. Recommendations include vaccination in accordance with Health Canada and National Advisory Committee on Immunization guidelines, with deferral of a second dose for patients with suspected myocarditis/pericarditis after the first dose of an mRNA vaccine.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt et al.
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Article
Medicine, General & Internal
Noam Barda et al.
Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Kirsten E. Shaw et al.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Jay Montgomery et al.
Summary: This study investigated cases of myocarditis occurring in male patients within the US Military Health System after receiving mRNA COVID-19 vaccines between January and April 2021. A total of 23 male patients presented with acute chest pain within 4 days post-vaccination, with elevated troponin levels and findings consistent with myocarditis on imaging. The number of cases observed was higher than expected after a second dose of the vaccine among male military members.
Article
Multidisciplinary Sciences
Mark J. Mulligan et al.
