Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

Article Biophysics

Assembly of model postsynaptic densities involves interactions auxiliary to stoichiometric binding

Yi-Hsuan Lin et al.

Summary: This study investigates the formation of functional biomolecular condensates through liquid-liquid phase separation (LLPS) and reveals the role of multiple interactions in the assembly process.

BIOPHYSICAL JOURNAL (2022)

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Article Virology

Dominant clade-featured SARS-CoV-2 co-occurring mutations reveal plausible epistasis: An in silico based hypothetical model

A. S. M. Rubayet Ul Alam et al.

Summary: This study examines how mutations in various branches of SARS-CoV-2 affect virus replication and transmission fitness, proposing a hypothetical model and demonstrating how certain key mutations impact viral infectivity and stability. The co-occurring mutations in different branches may have different effects on viral replication, requiring further research to understand the detailed molecular events.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Article Virology

Analysis of a crucial interaction between the coronavirus nucleocapsid protein and the major membrane-bound subunit of the viral replicase-transcriptase complex

Cheri A. Koetzner et al.

Summary: By genetic analysis and construction of mutants and chimeras, the role of the SR region of N protein in the interaction with viral replicase-transcriptase was studied. The central spacer was found to play a crucial role and its function was partially regulated by phosphorylation.

VIROLOGY (2022)

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Article Multidisciplinary Sciences

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

Baisheng Li et al.

Summary: This article reports the first local transmission of the Delta variant in mainland China. Compared to A/B lineage infections during the first wave in China in early 2020, Delta infections had viral loads that were on average about 1000 times greater when they first tested positive, suggesting potentially faster viral replication and greater infectiousness during early infection. The transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in most donor-recipient transmission pairs. However, transmission of minor intra-host variants resulted in at least 3 of the 34 substitutions identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load

Tobias Mourier et al.

Summary: Monitoring the spread and evolution of SARS-CoV-2 through genome sequencing is crucial in managing the COVID-19 pandemic. In this study, the authors sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia and identified two consecutive mutations in the nucleocapsid protein that were associated with higher viral loads in COVID-19 patients. Through biochemical analysis, they found that the mutant protein displayed enhanced viral RNA binding and differential interaction with key host proteins. The study also revealed dysregulated interferon response genes in host cells expressing the mutant protein. These findings provide important insights into the modulation of host-virus interactions and highlight the potential of the nucleocapsid protein as a target for drug development during infection.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

The intrinsically disordered SARS-CoV-2 nucleoprotein in dynamic complex with its viral partner nsp3a

Luiza Mamigonian Bessa et al.

Summary: The genome replication and transcription processes of SARS-CoV-2 are important targets for inhibiting the virus. The interaction between the nucleoprotein (N) and the amino-terminal ubiquitin-like domain of nsp3 (Ubl1), which is a cofactor of the replication-transcription complex, has been described at the atomic level. This interaction involves two linear motifs in the linker domain of N, which fold N around Ubl1 to regulate binding to RNA. The identification of these motifs provides future targets for developing innovative strategies against COVID-19.

SCIENCE ADVANCES (2022)

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Review Medicine, Research & Experimental

SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment

Dapeng Li et al.

Summary: This article summarizes representative SARS-CoV-2 neutralizing antibodies that have been reported and discusses prospects and challenges for the development of the next generation of COVID-19 preventive or therapeutic antibodies.

ANNUAL REVIEW OF MEDICINE (2022)

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Article Biochemistry & Molecular Biology

High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2

Luca Zinzula et al.

Summary: The Covid-19 pandemic caused by SARS-CoV-2 is a global health crisis with unprecedented casualties and socio-economic burden. The N nucleocapsid phosphoprotein of SARS-CoV-2 plays a crucial role in oligomerizing and packaging the viral genome, making it a potential antiviral target. Structural and biophysical studies have revealed the importance of the N C-terminal domain in N protein oligomerization and ssRNA binding.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Microbiology

Nucleocapsid mutations R203K/G204R increase the infectivity, fitness, and virulence of SARS-CoV-2

Haibo Wu et al.

Summary: The study found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid protein contribute to the emergence of high-transmissibility variants with replication advantages. These variants show increased infectivity in human lung cells and hamsters, with a positive association observed between increased COVID-19 severity and sample frequency of these mutations.

CELL HOST & MICROBE (2021)

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Review Chemistry, Medicinal

What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design

Muya Xiong et al.

Summary: The emergence of various coronaviruses in recent decades has posed significant threats to global health, with the ongoing COVID-19 pandemic causing millions of infections and deaths worldwide. The 3C-like protease (3CL(pro)) is seen as a promising target for antiviral intervention due to its essential role in viral replication and its conserved structural features among different coronaviruses. Research focusing on the crystal structures of 3CL(pro) and their inhibitors aims to provide insights into inhibition mechanisms and guide future drug discovery efforts.

MEDICINAL RESEARCH REVIEWS (2021)

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Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

Shan Lu et al.

Summary: The SARS-CoV-2 nucleocapsid (N) protein binds viral RNA and undergoes liquid-liquid phase separation driven by its central intrinsically-disordered region, modulated by phosphorylation. Additionally, the N protein interacts with the membrane protein M to form mutually exclusive compartments in a three-component mixture with RNA.

NATURE COMMUNICATIONS (2021)

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Article Microbiology

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

Robert M. Cox et al.

Summary: Treating SARS-CoV-2-infected ferrets with nucleoside analogue MK-4482/EIDD-2801 reduced viral load and suppressed virus spread. This therapeutic approach shows promise in breaking transmission chains of the COVID-19 pandemic.

NATURE MICROBIOLOGY (2021)

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Letter Infectious Diseases

The Delta SARS-CoV-2 variant has a higher viral load than the Beta and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients

Elisa Teyssou et al.

JOURNAL OF INFECTION (2021)

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Article Biophysics

The highly flexible disordered regions of the SARS-CoV-2 nucleocapsid N protein within the 1-248 residue construct: sequence-specific resonance assignments through NMR

Marco Schiavina et al.

Summary: The study focuses on the nucleocapsid protein N from SARS-CoV-2, specifically the 1-248 construct, and reports the sequence-specific assignment of two disordered regions within this protein. This is a significant step towards the complete characterization of the protein.

BIOMOLECULAR NMR ASSIGNMENTS (2021)

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Article Biophysics

Standard protocol for mass photometry experiments

Di Wu et al.

Summary: Mass photometry is a rapidly expanding experimental technique that measures the mass distribution of molecules in solution. It offers speed, sensitivity, and low sample consumption without the need for labeling or immobilization, making it stand out from other analytical methods. Increase in the number of laboratories using mass photometry for routine sample analysis highlights its advantages for consistent data collection and documentation.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2021)

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Article Multidisciplinary Sciences

Rapid assessment of SARS-CoV-2-evolved variants using virus-like particles

Abdullah M. Syed et al.

Summary: Efforts to determine the improved fitness of new SARS-CoV-2 variants have been limited to analyzing spike protein mutations. This study shows that SC2-VLPs can deliver exogenous transcripts, allowing analysis of mutations in all structural proteins. Specific nucleocapsid mutations were found to independently increase messenger RNA delivery and expression, shedding light on mechanisms behind the increased spread of variants.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Genomic diversity of SARS-CoV-2 in Oxford during United Kingdom's first national lockdown

Altar M. Munis et al.

Summary: Modeling the spread of SARS-CoV-2 is crucial for understanding and containing outbreaks, with mutations in viral genomes impacting virulence. Analyzing 563 clinical samples in Oxford during the first wave of infections in the UK allowed researchers to track short-term viral evolution, detect mutations of concern, and capture viral diversity, demonstrating the utility of genomic pathogen surveillance in controlling local virus spread.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity

Alex Graudenzi et al.

Summary: This study conducted a large-scale analysis of intra-host genomic diversity of SARS-CoV-2, revealing interactions between host-related mutational processes and transmission dynamics, as well as identifying mutational signatures related to nucleotide substitutions. The study also demonstrated the impact of purifying selection on these mutational processes, while some mutations transition towards clonality, increasing overall genomic diversity. Additionally, phylogenomic analysis supported the hypothesis of transmission of minor variants, paving the way for integrated analysis of intra-host genomic diversity and clinical outcomes of SARS-CoV-2 infections.

ISCIENCE (2021)

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Article Biophysics

1H, 13C and 15N Backbone chemical shift assignments of the n-terminal and central intrinsically disordered domains of SARS-CoV-2 nucleoprotein

Serafima Guseva et al.

Summary: The nucleoprotein (N) from SARS-CoV-2 plays an important role in the viral replication transcription complex and in protecting the viral genome from the host immune system. N is a 419 amino acid multidomain protein with two folded domains and a predicted intrinsically disordered region, for which atomic resolution information is currently lacking.

BIOMOLECULAR NMR ASSIGNMENTS (2021)

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Article Microbiology

Historical Perspective on the Discovery of the Quasispecies Concept

Esteban Domingo et al.

Summary: Viral quasispecies are dynamic distributions of nonidentical but closely related mutant and recombinant viral genomes that undergo genetic variation, competition, and selection. The concept originated from a model for the origin of life and experimental evidence from bacteriophage clones. Quasispecies dynamics reveal complexities in viral population behavior with implications for disease mechanisms and control strategies.

ANNUAL REVIEW OF VIROLOGY, VOL 8 (2021)

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Article Biochemistry & Molecular Biology

The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins

Kristina Tugaeva et al.

Summary: Phosphorylated SARS-CoV-2 N protein binds to 14-3-3 protein, potentially playing a crucial role in nucleocytoplasmic shuttling and other functions. A critical phosphorylation site located within the SR-rich region of N, which is conserved among related coronaviruses, interacts with all seven human 14-3-3 isoforms.

JOURNAL OF MOLECULAR BIOLOGY (2021)

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Article Multidisciplinary Sciences

GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein

Ming Zhao et al.

Summary: RNA triggers liquid-liquid phase separation (LLPS) of the SARS-CoV-2 nucleocapsid protein N, confirming its role in infection. Chemical compound (-)-gallocatechin gallate (GCG) disrupts N's LLPS and inhibits viral replication, suggesting a potential treatment option for COVID-19.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Jasmine Cubuk et al.

Summary: The study reveals that SARS-CoV-2 nucleocapsid (N) protein undergoes liquid-liquid phase separation with RNA, and provides molecular details of N protein through single-molecule spectroscopy with all-atom simulations, showing its multivalent RNA-binding nature and interactions that may drive RNA compaction.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Comparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2

Ian McDonald et al.

Summary: This study provides a comparative evaluation of different vaccine platforms in terms of immunogenicity and efficacy. Vaccines generally result in mild and self-limiting adverse events. Different vaccines show varying levels of immunogenicity and efficacy.

NPJ VACCINES (2021)

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Article Multidisciplinary Sciences

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

Huaying Zhao et al.

Summary: The study shows that interactions between the N protein and oligonucleotides lead to the formation of ribonucleoprotein particles. Short oligonucleotide lengths result in compact complexes, while longer lengths promote the formation of higher-order complexes and droplet growth.

ISCIENCE (2021)

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Article Biochemistry & Molecular Biology

Analysis of SARS-CoV-2 nucleocapsid phosphoprotein N variations in the binding site to human 14-3-3 proteins

Samanta Del Veliz et al.

Summary: The study explored the interaction between the SARS-CoV-2 N protein and cell host proteins including 14-3-3γ, analyzing the impact of mutations on binding energy. Mutations with positive effects on the interaction were found to be most prevalent in the phylogenetic tree, with compensatory mutations identified to maintain interaction energy. The results suggest that the N-14-3-3γ binding is beneficial for the virus, highlighting the potential for targeting this viral-host protein-protein interaction in antiviral strategies.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

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Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

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Review Genetics & Heredity

The biological and clinical significance of emerging SARS-CoV-2 variants

Kaiming Tao et al.

Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.

NATURE REVIEWS GENETICS (2021)

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Article Multidisciplinary Sciences

Ongoing global and regional adaptive evolution of SARS-CoV-2

Nash D. Rochman et al.

Summary: The evolution of SARS-CoV-2 during the COVID-19 pandemic is primarily characterized by purifying selection, with a small number of sites evolving under positive selection. Variants in the spike protein's receptor-binding domain and the nucleocapsid protein region with NLS are enriched with positively selected amino acid replacements. These replacements form a connected network of apparent epistatic interactions and are indicators of major partitions in the SARS-CoV-2 phylogeny. The global virus diversity has been steadily increasing, with distinct periods based on phylogenetic distances and key mutations.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase

Tae Hun Kim et al.

Summary: The role of biomolecular condensates in biological function and the importance of dynamic interactions involving intrinsically disordered protein regions (IDRs) in their assembly are increasingly recognized. Using NMR methods to study condensed IDR states of CAPRIN1 has provided insights into interactions driving phase separation, such as ATP interactions and the effects of O-GlcNAcylation. The expanded NMR toolkit developed for characterizing IDR condensates has the potential to inform models of phase separation and dynamic structure-function relationships in other biological condensates.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Microbiology

Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks

Katarina M. Braun et al.

Summary: The study shows that within-host diversity of SARS-CoV-2 is low and transmission bottlenecks are narrow, with most infections founded by very few viruses. Within-host variants are rarely transmitted, even within the same household, and are seldom detected along phylogenetically linked infections within the broader community. This suggests that most variation generated within-host is lost during transmission.

PLOS PATHOGENS (2021)

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Article Multidisciplinary Sciences

Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain

Chao Wu et al.

Summary: The study characterizes the biochemical properties of the nucleocapsid protein N encoded by SARS-CoV-2 and highlights the value of using N domains as highly specific and sensitive diagnostic markers. The research provides insights into N oligomerization, RNA binding, phosphorylation regulation, and immunogenicity of different N domains.

ISCIENCE (2021)

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Article Biotechnology & Applied Microbiology

Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silico

Syeda Tasnim Quayum et al.

Summary: Mutations in the nucleocapsid protein of SARS-CoV-2 can significantly alter its interaction with the M protein, leading to an increase in the number of salt bridges formed and a decrease in temperature sensitivity compared to the wild type counterpart.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

The molecular assessment of SARS-CoV-2 Nucleocapsid Phosphoprotein variants among Indian isolates

Gajendra Kumar Azad

Summary: COVID-19, caused by SARS-CoV-2, is rapidly spreading with high mutation rates, as shown by the twenty mutations found among Indian isolates. Some of these mutations impact the secondary structure of the N protein.

HELIYON (2021)

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Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Tyler N. Starr et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Molecular Architecture of the SARS-CoV-2 Virus

Hangping Yao et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design

Ya Peng et al.

EMBO JOURNAL (2020)

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Article Multidisciplinary Sciences

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

Ayal B. Gussow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Biochemistry & Molecular Biology

Architecture and self-assembly of theSARS-CoV-2 nucleocapsid protein

Qiaozhen Ye et al.

PROTEIN SCIENCE (2020)

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Article Cell Biology

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Andrea J. Pruijssers et al.

CELL REPORTS (2020)

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Article Genetics & Heredity

Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes

Asaf Poran et al.

GENOME MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions

Christopher R. Carlson et al.

MOLECULAR CELL (2020)

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Article Biochemistry & Molecular Biology

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

Christiane Iserman et al.

MOLECULAR CELL (2020)

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Widespread occurrence of the droplet state of proteins in the human proteome

Maarten Hardenberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell Biology

Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2 Alexandra

Alexandra Popa et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

Adriana Savastano et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Steffen Klein et al.

NATURE COMMUNICATIONS (2020)

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Article Microbiology

Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein

Dhurvas Chandrasekaran Dinesh et al.

PLOS PATHOGENS (2020)

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Article Biochemistry & Molecular Biology

Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein

Renjie Zhou et al.

MOLECULAR BIOMEDICINE (2020)

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Article Biology

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

Taraneh Zarin et al.

ELIFE (2019)

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Article Genetics & Heredity

Liquid–Liquid Phase Separation in Disease

Simon Alberti et al.

Annual Review of Genetics (2019)

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Review Virology

Coronavirus genomic RNA packaging

Paul S. Masters

VIROLOGY (2019)

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Article Genetics & Heredity

Viral quasispecies

Esteban Domingo et al.

PLOS GENETICS (2019)

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Nextstrain: real-time tracking of pathogen evolution

James Hadfield et al.

BIOINFORMATICS (2018)

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Article Biochemical Research Methods

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Jing Huang et al.

NATURE METHODS (2017)

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Data, disease and diplomacy: GISAID's innovative contribution to global health

Stefan Elbe et al.

GLOBAL CHALLENGES (2017)

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Letter Biochemical Research Methods

The I-TASSER Suite: protein structure and function prediction

Jianyi Yang et al.

NATURE METHODS (2015)

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The Phyre2 web portal for protein modeling, prediction and analysis

Lawrence A. Kelley et al.

NATURE PROTOCOLS (2015)

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Review Pharmacology & Pharmacy

The SARS coronavirus nucleocapsid protein - Forms and functions

Chung-ke Chang et al.

ANTIVIRAL RESEARCH (2014)

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Mutational and fitness landscapes of an RNA virus revealed through population sequencing

Ashley Acevedo et al.

NATURE (2014)

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Deciphering key features in protein structures with the new ENDscript server

Xavier Robert et al.

NUCLEIC ACIDS RESEARCH (2014)

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Article Multidisciplinary Sciences

A biophysical protein folding model accounts for most mutational fitness effects in viruses

C. Scott Wylie et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Biochemistry & Molecular Biology

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

Chia-Hsin Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Review Chemistry, Multidisciplinary

CHARMM: The Biomolecular Simulation Program

B. R. Brooks et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

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Review Biochemistry & Molecular Biology

Do viral proteins possess unique biophysical features?

Nobuhiko Tokuriki et al.

TRENDS IN BIOCHEMICAL SCIENCES (2009)

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COBALT: constraint-based alignment tool for multiple protein sequences

Jason S. Papadopoulos et al.

BIOINFORMATICS (2007)

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Transient disulfide bonds formation in conformational maturation of influenza virus nucleocapsid protein (NP)

EN Prokudina et al.

VIRUS RESEARCH (2004)

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Plasticity in structure and assembly of SARS-CoV-2 nucleocapsid protein

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