期刊
CHEMICAL SCIENCE
卷 13, 期 22, 页码 6519-6524出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2sc00036a
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资金
- National Natural Science Foundation of China [21472060, 21772058, 21072071]
- 111 Project [B17019]
- CCNU from the colleges' basic research and operation of MOE [CCNU17CG0011, CCNU17KYZHSY07, CCNU18KYZHSY06]
- Chemistry and Chemical Engineering Guangdong Laboratory [1922003]
- Guangdong Major Project of Basic and Applied Basic Research [2019B030302009]
Visible-light-induced reactions play an important role in organic synthesis, but efficient photochemical synthesis of enantiomerically pure molecules remains a challenge. This study describes a simple and efficient visible-light-induced reaction for the synthesis of P-chiral heteroaryl phosphine oxides.
Over the past two decades, visible-light-induced transformations have been regarded as being among the most environmentally benign and powerful strategies for constructing complex molecules and diverse synthetic building blocks in organic synthesis. However, the development of efficient photochemical processes for assembling enantiomerically pure molecules remains a significant challenge. Herein, we describe a simple and efficient visible-light-induced C-P bond forming reaction for the synthesis of P-chiral heteroaryl phosphine oxides in moderate to high yields with excellent ee values (97-99% ee). Even in the absence of transition metal or photoredox catalysts, a variety of P-chiral heteroaryl phosphine oxides, including chiral diphosphine oxide 41, have been directly obtained under air conditions. Density functional theory (DFT) calculations have shown that the reaction involves intersystem crossing and single electron transfer to give a diradical intermediate under visible light irradiation.
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