Bimetal Biomimetic Engineering UtilizingMetal-Organic Frameworks for SuperoxideDismutase Mimic

In the past decade, scientists sought to engineernanomaterials with natural enzymes-like biological function,and searched for newfangled applications. Herein, we show thefirst example of utilizing a bimetal metal-organic framework(MOF-818) platform for mimicking of Cu/Zn-superoxidedismutase (Cu/Zn-SOD), an important antioxidant enzymethat specifically scavenges superoxide anions. Experimental dataand theoretical calculations reveal that the high Cu/Zn-SOD-like activity of MOF-818 results from the bimetal synergisticcatalysis, which is analogous to natural Cu/Zn-SOD. Such a bimetal biomimetic process allows for MOF-818 with much higherSOD-like activity, compared to the reported monometallic MOFs mimics. Moreover, the SOD-like MOF-818 displaysexcellent stability against heating, organic solvents, and denaturant treatments, which should inactivate natural enzymes. Basedon the catalytic mechanism, we also construct a MOF-818-based colorimetric sensing platform for phosphorylated peptidesand proteins detection. This work provides a new insight for biomimetic engineering, and may expedite the scale-upapplications of SOD-like nanozymes in variousfields.

Automated summary

In this study, scientists successfully used a bimetal metal-organic framework (MOF-818) platform to mimic Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and found that its SOD-like activity was higher compared to monometallic MOFs mimics. Additionally, they developed a colorimetric sensing platform based on MOF-818 for detecting phosphorylated peptides and proteins.