期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 132, 期 7, 页码 -出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI157124
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资金
- FASTER clinical studies
- Liverpool University Hospitals NHS Foundation Trust (LUHFT) Clinical Research Unit
- National Institute for Health Research (NIHR)
- University College London Hospitals NHS Foundation Trust
- Wellcome Trust Senior Fellowship [106917/Z/15/Z]
- NIHR Health Research Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections
- Centre of Excellence in Infectious Diseases Research (CEIDR)
- Alder Hey Charity via the Liverpool COVID-19 Partnership Strategic Research Fund
- Pfizer [WI255862-1]
This study investigated the relationship between SARS-CoV-2 and Streptococcus pneumoniae in different populations, and found that pneumococcal infection reduces host immune responses to the virus.
BACKGROUND. Although recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in patients with coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent contradiction may be explained by interactions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and pneumococci in the upper airway, resulting in the escape of SARSCoV-2 from protective host immune responses. METHODS. Here, we investigated the relationship of these 2 respiratory pathogens in 2 distinct cohorts of health care workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and patients with moderate to severe disease who presented to the hospital. We assessed the effect of coinfection on host antibody, cellular, and inflammatory responses to the virus. RESULTS. In both cohorts, pneumococcal colonization was associated with diminished antiviral immune responses, which primarily affected mucosal IgA levels among individuals with mild or asymptomatic infection and cellular memory responses in infected patients. CONCLUSION. Our findings suggest that S. pneumoniae impair host immunity to SARS-CoV-2 and raise the question of whether pneumococcal carriage also enables immune escape of other respiratory viruses and facilitates reinfection. TRIAL REGISTRATION. ISRCTN89159899 (FASTER study) and ClinicalTrials.gov NCT03502291 (LAIV study).
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