4.8 Review

Nanostructured particles assembled from natural building blocks for advanced therapies

期刊

CHEMICAL SOCIETY REVIEWS
卷 51, 期 11, 页码 4287-4336

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs00343g

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资金

  1. Australian Research Council Discovery Project [DP210103114]
  2. National Health and Medical Research Council Senior Principal Research Fellowship [GNT1135806]
  3. RMIT University
  4. Japan Society for the Promotion of Science (JSPS) [20F20373]
  5. National Natural Science Foundation of China [22178233]
  6. Talents Program of Sichuan Province, Double First Class University Plan of Sichuan University
  7. State Key Laboratory of Polymer Materials Engineering [sklpme 2020-03-01]
  8. Grants-in-Aid for Scientific Research [20F20373] Funding Source: KAKEN

向作者/读者索取更多资源

This review provides a comprehensive overview of the use of natural building blocks in advanced therapeutics, specifically focusing on nanostructured particles. The review summarizes the key scientific and preclinical milestones of these nanoparticles in advanced therapies and compares the advantages and disadvantages of different natural building blocks. Furthermore, it discusses current challenges and future research directions in the field.
Advanced treatments based on immune system manipulation, gene transcription and regulation, specific organ and cell targeting, and/or photon energy conversion have emerged as promising therapeutic strategies against a range of challenging diseases. Naturally derived macromolecules (e.g., proteins, lipids, polysaccharides, and polyphenols) have increasingly found use as fundamental building blocks for nanostructured particles as their advantageous properties, including biocompatibility, biodegradability, inherent bioactivity, and diverse chemical properties make them suitable for advanced therapeutic applications. This review provides a timely and comprehensive summary of the use of a broad range of natural building blocks in the rapidly developing field of advanced therapeutics with insights specific to nanostructured particles. We focus on an up-to-date overview of the assembly of nanostructured particles using natural building blocks and summarize their key scientific and preclinical milestones for advanced therapies, including adoptive cell therapy, immunotherapy, gene therapy, active targeted drug delivery, photoacoustic therapy and imaging, photothermal therapy, and combinational therapy. A cross-comparison of the advantages and disadvantages of different natural building blocks are highlighted to elucidate the key design principles for such bio-derived nanoparticles toward improving their performance and adoption. Current challenges and future research directions are also discussed, which will accelerate our understanding of designing, engineering, and applying nanostructured particles for advanced therapies.

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