期刊
JOURNAL OF THE ENDOCRINE SOCIETY
卷 6, 期 6, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/jendso/bvac060
关键词
continuous glucose monitoring; mean glucose; time in range; pediatric diabetes
资金
- Leona M. and Harry B. Helmsley Charitable Trust
This study aimed to establish reference glucose ranges in healthy young children without diabetes and found that these children had an average glucose level of 103 mg/dL (5.7 mmol/L), spent most of their time within the range of 70-140 mg/dL (3.9-7.8 mmol/L), and had minimal time below 70 mg/dL (3.9 mmol/L).
Context: Continuous glucose monitoring (CGM) is increasingly being used both for day-to-day management in patients with diabetes and in clinical research. While data on glycemic profiles of healthy, nondiabetic individuals exist, data on nondiabetic very young children are lacking. Objective: This work aimed to establish reference sensor glucose ranges in healthy, nondiabetic young children, using a current-generation CGM sensor. Methods: This prospective observational study took place in an institutional practice with healthy, nondiabetic children aged 1 to 6 years with normal body mass index. A blinded Dexcom G6 Pro CGM was worn for approximately 10 days by each participant. Main outcome measures included CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability. Results: Thirty-nine participants were included in the analyses. Mean average glucose was 103 mg/dL (5.7 mmol/L). Median percentage time between 70 and 140 mg/dL (3.9-7.8 mmol/L) was 96% (interquartile range, 92%-97%), mean within-individual coefficient of variation was 17 +/- 3%, median time spent with glucose levels greater than 140 mg/dL was 3.4% (49 min/day), and median time less than 70 mg/dL (3.9 mmol/L) was 0.4% (6 min/day). Conclusion: Collecting normative sensor glucose data and describing glycemic measures for young children fill an important informational gap and will be useful as a benchmark for future clinical studies.
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