Palladium-catalysed difluoroolefination of benzyl tosylates toward the synthesis of gem-difluoro-2-trifluromethyl styrene derivatives

We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram-scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the -CF3 group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.

Automated summary

An efficient method for accessing gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis has been presented. This method offers mild reaction conditions, broad substrate scope, and good product yields. Additionally, gram-scale reactions have demonstrated the robustness and potential of this method. Control experiments have shown that the -CF3 group is essential for the success of this transformation. Finally, the practicality of this method has been successfully proven through three synthetic applications.