期刊
EMERGING INFECTIOUS DISEASES
卷 28, 期 4, 页码 743-750出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2804.211907
关键词
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资金
- Initiative and Networking Fund of the Helmholtz Association of German Research Centers [SO-96]
- EU [101003480-CORESMA]
- State Ministry of Baden-Wurttemberg for Economic Affairs, Labor and, Tourism [FKZ 3-4332.62-NMI-68, FKZ 3-4332.62-NMI-67]
- European Regional Development Fund (Defeat Corona) [ZW7-8515131]
This study examines the immune responses in hemodialysis patients after vaccination and finds that 4 months after receiving the Pfizer-BioN-Tech BNT162b2 vaccine, the cellular and humoral responses against the original SARS-CoV-2 isolate and variants of concern are significantly reduced, and some patients have no detectable B- or T-cell responses.
Patients undergoing chronic hemodialysis were among the first to receive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased risk for severe coronavirus disease and high case-fatality rates. By using a previously reported cohort from Germany of at-risk hemodialysis patients and healthy donors, where antibody responses were examined 3 weeks after the second vaccination, we assessed systemic cellular and humoral immune responses in serum and saliva 4 months after vaccination with the Pfizer-BioN-Tech BNT162b2 vaccine using an interferon-. release assay and multiplex-based IgG measurements. We further compared neutralization capacity of vaccination-induced IgG against 4 SARS-CoV-2 variants of concern (Alpha, Beta, Gamma, and Delta) by angiotensin-converting enzyme 2 receptor-binding domain competition assay. Sixteen weeks after second vaccination, compared with 3 weeks after, cellular and humoral responses against the original SARS-CoV-2 isolate and variants of concern were substantially reduced. Some dialysis patients even had no detectable B- or T-cell responses.
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