期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 42, 页码 6200-6203出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01435a
关键词
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资金
- National Natural Science Foundation of China [91956117, 22071217, 21772175]
- Research Grants Council of Hong Kong (General Research Fund) [CUHK 14301820]
- Chinese University of Hong Kong (Faculty of Science, Direct Grant for Research)
- Zhejiang Provincial Natural Science Foundation of China [LY22B020008]
Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck-Suzuki reaction of 2-CF3-indoles have been developed. A variety of indolines bearing different stereocenters can be obtained using different reaction systems.
Highly enantioselective palladium-catalyzed dearomative reductive Heck reaction and domino Heck-Suzuki reaction of 2-CF3-indoles have been developed. Using Pd(OAc)(2)/(R)-Synphos as the catalyst and Et3SiH as a hydride source, a variety of indolines bearing a 2-trifluoromethyl quaternary stereocenter were obtained via a dearomative reductive Heck reaction. Alternatively, using Pd(dba)(2)/phosphoramidite as the catalyst and Ar4BNa as a coupling partner, structurally diverse indolines containing two vicinal carbon stereocenters were afforded through the domino dearomative Heck-Suzuki reaction.
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