4.2 Article

Dynamical systems theory of cellular reprogramming

期刊

PHYSICAL REVIEW RESEARCH
卷 4, 期 2, 页码 -

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AMER PHYSICAL SOC
DOI: 10.1103/PhysRevResearch.4.L022008

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资金

  1. Ministry of Education, Culture, Sports, Science, and Technol-ogy of Japan [17H06386]
  2. Japanese Society for the Promotion of Science [20H00123]
  3. Grants-in-Aid for Scientific Research [17H06386, 20H00123] Funding Source: KAKEN

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Cellular reprogramming involves erasing epigenetic memories of differentiated cells to regain pluripotency, achieved by overexpressing a few genes. The interplay between oscillatory gene expression and slower epigenetic modifications is perceived as a global attraction in this process.
In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of a few genes, resulting in regaining pluripotency, the potential for differentiation. Considering the interplay between oscillatory gene expression and slower epigenetic modifications, such reprogramming is perceived as an unintuitive, global attraction to the unstable manifold of a saddle, which represents pluripotency. The universality of this scheme is confirmed by the repressilator model and by gene regulatory networks that are randomly generated and extracted from embryonic stem cells.

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