期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 2, 期 11, 页码 1942-1950出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.6b00315
关键词
self-assembly; cyanine; NIR; photothermal therapy
资金
- National Natural Science Foundation of China [51522307, 51373167]
Near-infrared (NIR) imaging and photothermal therapy (PTT) based on the multifunctional cyanine dyes has shown great promise for cancer therapy. However, most of the PTT agents are often limited by low drug loading, short circulation time, and low biocompatibility. Herein, we developed cyanine-curcumin assembling nanoparticles (CCNPs) via a single-step reprecipitation method. IR-780-C4 (Cyc4) was employed as a photothermal and NIR imaging agent. Self-assembly of Cyc4 and curcumin in aqueous solution could be performed in the absence of surfactants or adjuvants, which is a simple and efficient way to fabricate nanomedicine with high drug loading. Formed CCNPs showed monodisper-sity, good stability in physiological conditions, and lower cytotoxicity. Moreover, CCNPs possess the high loading (70%) of cyanine dyes and a higher photothermal conversion efficacy than free Cyc4, which contribute to a decrease in the application dosage of cyanine dyes in cancer therapy. Importantly, CCNPs exhibited excellent NIR imaging capacity and photothermal tumor ablation under laser irradiation in vitro and in vivo. This work highlights the potential of using self-assembling of drug molecules to develop functional nanoparticles for drug delivery and cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据