Efficient preparation of unsymmetrical alkyl-aryl tellurides via a nickel-catalyzed reductive coupling strategy

Tellurium is a unique element, and the properties of tellurium-containing compounds are quite different from those of their sulfur and selenium homologues. In recent years, major advances have been made in organic sulfur and selenium chemistry, but organotellurides have been relatively underexplored. Herein is described a selective cross-coupling between unactivated alkyl bromides and diaryl tellurides through reductive nickel catalysis, a process that efficiently led to unsymmetrical alkyl-aryl tellurides. This strategy featured mild reaction conditions, excellent yields, easily available substrates, and a wide substrate scope.

Automated summary

In this study, a selective cross-coupling reaction between unactivated alkyl bromides and diaryl tellurides was achieved using reductive nickel catalysis, leading to the synthesis of unsymmetrical alkyl-aryl tellurides with mild reaction conditions, high yields, easily accessible substrates, and a broad substrate scope.