期刊
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
卷 306, 期 6, 页码 2155-2166出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00404-022-06587-0
关键词
Endometrial cancer; Endometrial tissue; H-1-NMR; Metabolomics
资金
- Scientific Research Projects Unit of Inonu University [TCD-2021-2359]
- Scientific and Technological Research Council of Turkey (TUBITAK) [120C152]
This study analyzed the metabolite profiles in patients with endometrial cancer and found increased levels of lactate, glucose, and various other substances.
Purpose To analyze endometrial metabolite profiles between patients with endometrial cancer and controls. Methods Seventeen (17) women with endometrium cancer and 18 controls were enrolled in this study. H-1 HR-MAS (High Resolution-Magic Angle Spinning) NMR (Nuclear Magnetic Resonance) spectroscopy data obtained from endometrial tissue samples of patients with endometrial cancer and control group were analyzed with bioinformatics methods. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of pre-processed spectral data shows a separation between the samples from patients with endometrial cancer and controls. Analysis results suggest that the levels of lactate, glucose, o-phosphoethanolamine, choline, glycerophosphocholine, phosphocholine, leucine, isoleucine, valine, glutamate, glutamine, n-acetyltyrosine, methionine, taurine, alanine, aspartate and phenylalanine are increased in patients with endometrial cancer compared to the controls. Conclusion The metabolomics signature of patients with endometrial cancer is different from that of benign endometrial tissue.
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