Connexin43 in Musculoskeletal System: New Targets for Development and Disease Progression

Connexin43, which is the most highly expressed connexin subtype in the musculoskeletal system, exists in a variety of bone cells, synovial tissue, and cartilage tissue. Connexin43 has been suggested to be a key regulator of bone homeostasis. Studies have shown aberrant Connexin43 expression in musculoskeletal disorders, such as osteoporosis, osteoarthritis, and rheumatoid arthritis. During cellular activities, Connexin43 can participate in the formation of functionally specific gap junctions and hemichannels and can exert independent cellular regulatory and signaling functions through special C-termini. The critical role of Connexin43 in physiological development and disease progression has been gradually revealed. In this article, the function of Connexin43 in musculoskeletal tissues is summarized, revealing the potential role of Connexin43 as a key target in the treatment of related bone and muscle disorders and the need for further discovery.

Automated summary

This article summarizes the function of Connexin43 in musculoskeletal tissues and its abnormal expression in related disorders. Studies have shown that Connexin43 plays an important role in bone homeostasis regulation. By forming gap junctions and hemichannels, Connexin43 can participate in cellular regulation and signaling. This article highlights the importance of Connexin43 as a potential target for the treatment of related bone and muscle disorders and emphasizes the need for further research.