期刊
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
卷 11, 期 2, 页码 160-167出版社
ASIA-PACIFIC ACAD OPHTHALMOLOGY-APAO
DOI: 10.1097/APO.0000000000000510
关键词
diabetic retinopathy; eye drops; neurodegeneration; neurovascular unit; treatment
资金
- Instituto de Salud Carlos III [PI19/01 215, ICI20/00129]
- Ministerio de Economia y Competitividad [PID2019104225RB-I00]
This article provides an overview of the main components and underlying mechanisms of neurodegeneration in diabetic retinopathy, as well as the relevant experimental models. Additionally, it critically reviews the results of neuroprotective treatments and identifies research gaps that need to be addressed.
Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy, the leading cause of preventable blindness. The hallmarks of diabetes-induced neurodegeneration are neural cell apoptosis and glial activation, which seem even before vascular lesions can be detected by ophthalmoscopic examination. The molecular mediators of retinal neurodegeneration include proinflamma- tory cytokines, oxidative stress, mitochondrial dysfunction, and the molecular pathways closely related to chronic hyperglycemia. In this article, an overview of the main components of neurodegeneration, its key underlying mechanisms, and the more useful experimental models for investigative purposes will be given. In addition, the results of most relevant treatments based on neuroprotection, and the research gaps that should be filled will be critically reviewed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据